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Natl Ctr Global Hlth & Med, Res Ctr Hepatitis & Immunol, Dept Gastroenterol, Res Inst,Shinjuku Ku, Tokyo 1628655, Japan Natl Ctr Global Hlth & Med, Res Ctr Hepatitis & Immunol, Dept Gastroenterol, Res Inst,Shinjuku Ku, Tokyo 1628655, Japan