缺血性中风治疗新策略——靶向神经血管单元

被引：25

作者：

高梅

刘睿

杜冠华

机构：

[1] 中国医学科学院药物研究所

来源：

中国临床药理学与治疗学 | 2008年 / 07期

关键词：

中风; 神经血管单元; 血脑屏障; 基质金属蛋白酶;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

100204 [神经病学];

摘要：

近20年来,对缺血性中风发生后脑细胞不可逆损伤的机制进行了大量的研究,重点探讨了导致神经元死亡的原因以及使神经元抵御死亡的策略。应用溶栓药物的临床经验已经证明早期的再灌注能够改善缺血症状。近来的研究着眼于通过血管和细胞机制来减轻组织损伤,研究血管系统与大脑细胞之间如何相互通讯。基于对血管和神经系统的功能认识,形成了神经血管单元(neurovascular unit)的概念。这一新的研究焦点为中风的研究和治疗带来了新的机遇和挑战。

引用

页码：813 / 821

页数：9

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