Th17细胞及其与肿瘤发生发展的关系

被引:25
作者
王伟伟
沈茜
机构
[1] 第二军医大学附属长海医院实验诊断科
关键词
肿瘤; T淋巴细胞,辅助诱导; 白细胞介素类; Th17细胞;
D O I
暂无
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
100214 [肿瘤学];
摘要
辅助性T细胞17(T helper 17 cells,Th17)以表达IL-17而得名,是不同于Th1、Th2的CD4+T细胞新亚群,在其分化发育过程中受转化生长因子-β(transforming growth factor beta,TGF-β)和IL-6以及IL-23、IL-21等细胞因子的调节。Th17参与机体的免疫应答、炎症反应和自身免疫性疾病等,同时也在肿瘤的发生发展中发挥着重要作用。因此有关Th17在肿瘤中的表达和作用机制的研究可以为肿瘤预防、早期诊断和治疗提供新的突破。
引用
收藏
页码:700 / 703
页数:4
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