新的易损斑块血清标志物妊娠相关蛋白A研究进展

被引：6

作者：

吴小凡 ^{[1
]}

陈韵岱 ^{[2
]}

王绿娅 ^{[3
]}

吕树铮 ^{[1
]}

机构：

[1] 首都医科大学附属北京安贞医院心内科

[2] 中国人民解放军总医院

[3] 北京市心肺血管疾病研究所

来源：

现代生物医学进展 | 2010年 / 10卷 / 02期

关键词：

妊娠相关蛋白-A; 易损斑块; 急性冠脉综合症;

D O I：

10.13241/j.cnki.pmb.2010.02.026

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

冠状动脉易损斑块破裂或腐蚀继发血栓形成是急性冠脉事件发生的病理基础,寻找易损斑块新血清标记物对于早期识别和干预高危患者至关重要。新近发现妊娠相关蛋白A(PAPP-A)参与动脉粥样硬化的发生发展,并且与斑块的不稳定性关系密切,是冠心病患者不良事件的预测因子。本综述主要介绍妊娠相关蛋白-A的生物学特性及其与心血管疾病以及易损斑块关系的研究进展,为临床诊断和治疗带来新的思路。

引用

页码：359 / 361

页数：3

共 35 条

[1] Genetic polymorphism in, the pregnancy-associated plasma protein-A associated with acute myocardial infarction [J].

Park, Sungha ;

Youn, Jong-Chan ;

Shin, Dong-Jik ;

Park, Chan-Mi ;

Kim, Jung-Sun ;

Ko, Young-Guk ;

Choi, Donghoon ;

Ha, Jong-Won ;

Jang, Yangsoo ;

Chung, Namsik .

CORONARY ARTERY DISEASE, 2007, 18 (06) :417-422

[2]

Pregnancy Associated Plasma Protein A, a Novel, Quick, and Sensitive Marker in ST-Elevation Myocardial Infarction[J] . Kasper K. Iversen,Ane S. Teisner,Borge Teisner,Anette Kliem,Pia Thanning,Peer Grande,Peter Clemmensen. &nbspThe American Journal of Cardiology . 2008 (10)

[3]

Prognostic value of circulating pregnancy-associated plasma protein-A （PAPP-A） and proform of eosinophil major basic protein （pro-MBP） levels in patients with chronic stable angina pectoris[J] . Luciano Consuegra-Sanchez,Ivana Petrovic,Juan Cosin-Sales,David W. Holt,Michael Christiansen,Juan Carlos Kaski. &nbspClinica Chimica Acta . 2008 (1)

[4] Release patterns of pregnancy-associated plasma protein A in patients with acute coronary syndromes assessed by an optimized monoclonal antibody assay [J].

Schoos, Mikkel ;

Iversen, Kasper ;

Teisner, Ane ;

Teisner, Borge ;

Thaning, Pia ;

Kliem, Anette ;

Grande, Peer ;

Clemmensen, Peter .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2009, 69 (01) :121-127

[5] Usefulness of Pregnancy-Associated Plasma Protein A in Patients With Acute Coronary Syndrome [J].

Iversen, Kasper K. ;

Dalsgaard, Morten ;

Teisner, Ane S. ;

Schoos, Mikkel ;

Teisner, Borge ;

Nielsen, Henrik ;

Clemmensen, Peter ;

Grande, Peer .

AMERICAN JOURNAL OF CARDIOLOGY, 2009, 104 (11) :1465-1471

[6] C反应蛋白和肿瘤坏死因子-α对单核细胞妊娠相关血浆蛋白-AmRNA表达影响的实验研究 [J].

李卫萍 ;

顾复生 ;

贾三庆 .

中华心血管病杂志, 2006, (12) :1117-1121

[7]

Virtual histology intravascular ultrasound analysis of attenuated plaques detected by grayscale in-travascular ultrasound in patients with acute coronary syndromes:A PROSPECT substudy. Wu XF,Maehara A,Mintz GS,et al. The American Journal of Cardiology . 2010

[8]

Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. Park S,Youn JC,Shin DJ,Park CM,Kim JS,Ko YG,Choi D,Ha JW,Jang Y,Chung N. Coronary Artery Disease . 2007

[9]

Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues. Overgaard M T, Oxvig C, Christiansen M, et al. Biology of Reproduction . 1999

[10]

Targeted Disruption of the Pregnancy-Associated Plasma Protein-A Gene Is Associated with Diminished Smooth Muscle Cell Response to Insulin-like Growth Factor-I and Resistance to Neointimal Hyperplasia after Vascular Injury. Zachary T,Simari,Robert D,Conover,Cheryl A. The Journal of Endocrinology . 2006

← 1 2 3 4 →