慢性脑灌流不足大鼠缺氧诱导因子-1α与血管内皮生长因子的表达

被引：1

作者：

周艳

章军建

张晓琴

机构：

[1] 武汉大学中南医院神经科

来源：

中国临床神经科学 | 2003年 / 04期

关键词：

慢性脑灌流不足; 缺氧诱导因子-la; 血管内皮生长因子;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

100205 ;

摘要：

目的:观察大鼠在慢性脑灌流不足状态下缺氧诱导因子(HIF-1α)和血管内皮生长因子(VEGF)的表达,探讨慢性脑灌流不足的代偿与适应机制。方法:本研究采用永久性双侧颈总动脉结扎(2VO)制备动物模型;运用Westem印迹检测2 VO后1d和6周时HIF-1α和VEGF的表达。结果:海马HIF-1α和VEGF蛋白表达水平1d即上升,6周时进一步升高。结论:慢性脑灌流不足时HIF-1α和VEFG表达上调,可能参与了慢性脑灌流不足的代偿与适应机制。

引用

页码：333 / 334+337 +337

页数：3

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