尼可地尔对急性心肌梗死患者介入治疗术后心肌灌注影响附视频

被引：10

作者：

刘海珍

林琍

宗文霞

李昌

机构：

[1] 湖北省中山医院心血管内科

来源：

医药导报 | 2013年 / 12期

关键词：

尼可地尔; 心肌梗死; 血管成形术;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

目的观察尼可地尔对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)后的心肌保护作用。方法 120例成功实施PCI的急性STEMI患者,采用随机数字表法分为对照组57例和治疗组63例。对照组给予常规治疗,治疗组在常规治疗基础上加服尼可地尔片5 mg,tid,疗程为6个月。治疗前后两组患者行超声心动图检查,分别测定室壁异常节段数、左室舒张末容积(LVEDV)、左室射血分数(LVEF),室壁节段运动评分指数(WMSI),行同位素心肌显像测定,并观察住院及门诊随访期间所有患者心绞痛发作情况。结果治疗6个月后,治疗组的异常室壁运动节段恢复率明显高于对照组(68.8%比51.2%,P<0.05);治疗组LVEDV增加比率较对照组明显降低(P<0.05),LVEF恢复较对照组明显增高(P<0.05);6个月后治疗组WMSI、同位素心肌显像评分指数均较对照组有显著降低(P<0.05);6个月期间治疗组心绞痛发生比例较对照组显著降低(P<0.05)。结论尼可地尔能缩小心肌梗死面积,改善心肌梗死相关部位的室壁活动状态,减少心绞痛发作,有利于改善心功能。

引用

页码：1594 / 1596

页数：3

共 7 条

[1] 尼可地尔治疗冠心病稳定型心绞痛68例 [J].

吴文利 ;

梅霞 ;

罗羽慧 .

中国药业, 2005, (05) :65-66

[2]

Once Daily Therapy With Isosorbide-5-Mononitrate Causes Endothelial Dysfunction in Humans[J] . George R. Thomas,Jonathan M. DiFabio,Tommaso Gori,John D. Parker.Journal of the American College of Cardiology . 2007 (12)

[3]

Nicorandil suppressed myocardial injury after percutaneous coronary intervention[J] . Tsuyoshi Isono,Hiroshi Kamihata,Yasuo Sutani,Masayuki Motohiro,Satoshi Yamamoto,Shiori Kyoui,Yoshiji Iharada,Kouji Kurimoto,Katsuko Hara,Hakuo Takahashi,Toshiji Iwasaka.International Journal of Cardiology . 2007 (2)

[4]

NICORANDIL ATTENUATES NF-κB ACTIVATION, ADHESION MOLECULE EXPRESSION, AND CYTOKINE PRODUCTION IN PATIENTS WITH CORONARY ARTERY BYPASS SURGERY[J] . Takae Kawamura,Mamoru Kadosaki,Noriko Nara,Jicheng Wei,Shigeatsu Endo,Katsuya Inada.Shock . 2005 (2)

[5] Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis [J].

Sekiya, M ;

Sato, M ;

Funada, J ;

Ohtani, T ;

Akutsu, H ;

Watanabe, K .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2005, 46 (01) :63-67

[6]

Further insights into the no-reflow phenomenon after primary angioplasty in acute myocardial infarction: The role of microthromboemboli[J] . Tadamichi Sakuma,Howard Leong-Poi,Nick G. Fisher,Norman C. Goodman,Sanjiv Kaul.Journal of the American Society of Echocardiography . 2003 (1)

[7] Multiple endothelial injury in epicardial coronary artery induces downstream microvascular spasm as well as remodeling partly via thromboxane A2 [J].

Saitoh, S ;

Onogi, F ;

Aikawa, K ;

Muto, M ;

Saito, T ;

Maehara, K ;

Maruyama, Y .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (01) :308-315

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