依达拉奉联合重组组织型纤溶酶原激活剂治疗急性脑梗死的疗效观察

被引:21
作者
田强 [1 ]
张美增 [2 ]
机构
[1] 陕西省城固县人民医院神经内科
[2] 青岛大学医学院附属医院神经内科
关键词
重组组织型纤溶酶原激活剂; 依达拉奉; 溶栓; 急性脑梗死;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
目的观察依达拉奉联合重组组织型纤溶酶原激活剂(rt-PA)治疗急性脑梗死的临床疗效及安全性。方法对52例符合纳入标准发病6h内的急性脑梗死病人,随机分为治疗组(26例)和对照组(26例)。常规治疗的同时,治疗组给予依达拉奉联合rt-PA治疗,对照组给予rt-PA治疗。以欧洲脑梗死临床神经缺损评分标准(ESS)和日常生活能力指数(BI)进行疗效判定。结果治疗后7、14、21d的ESS评分,治疗组明显高于对照组,3个月后治疗组的总有效率(84.6%)明显优于对照组(61.5%)(P<0.05)。治疗组与对照组出凝血检查和不良反应比较,其差异性无统计学意义(P>0.05)。结论依达拉奉联合rt-PA治疗急性脑梗死是安全有效的,能显著改善患者的预后。
引用
收藏
页码:196 / 198
页数:3
相关论文
共 8 条
  • [1] 静脉rtPA溶栓治疗脑梗死的安全性与有效性
    陶庆玲
    赵晖
    许敏
    [J]. 中国临床医学, 2004, (04) : 485 - 487
  • [3] Efficacy of edaravonea free radica scavenger,for the treat ment of acute lacunar infarction. Ishinaa M. Neurologia Medico Chirurgica . 2005
  • [4] Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. The National Institute of Neurological Disorders and Stroke rt PA Stroke Study Group. New England Journal of Medicine, The . 1995
  • [5] Safety and efficacy of intravenous tissue plasminogen activator stroke treatment in the 3-to 6-hour window using multimodal transcranial Doppler/MRI selection protocol. Ribo,M.,Molina,C.A.,Rovira,A. Stroke . 2005
  • [6] Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Adams H,Adams R,Del Zoppo G,et al. Stroke . 2005
  • [7] Oxidative stress in the context of acute cerebrovascular stroke. El Kossi MM,Zakhary MM. Stroke . 2000
  • [8] Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction.Randomized, placebo-controlled, double-blind study at multicenters. Edaravone Acute Infarction Study Group. Cerebrovascular Diseases . 2003