凋亡抑制蛋白Livin:抗癌新靶点

被引：11

作者：

梁春艳

马萍

机构：

[1] 中国医科大学附属第一医院肿瘤研究所第二研究室

来源：

现代肿瘤医学 | 2008年 / 06期

关键词：

Livin; 细胞凋亡; 肿瘤治疗;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 ;

摘要：

Livin,又称ML-IAP或KIAP是与肿瘤发生发展密切相关的凋亡抑制蛋白家族(inhibitor of apoposis proteins,IAPs)中的新成员,能够与内源IAP抑制剂SMAC和caspase-3,caspase-7,caspase-9结合,发挥抗细胞凋亡的作用。它特异性高表达于肿瘤组织而使肿瘤组织对放化疗作用变得耐受。近来,体内外研究表明下调或抑制Livin基因表达增加了肿瘤细胞凋亡率,抑制肿瘤细胞的增殖和集落形成能力,提高肿瘤细胞对化疗药物和放疗的敏感性。Livin将成为肿瘤治疗的潜在靶点。

引用

页码：1055 / 1058

页数：4

共 30 条

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