活性氧、钙和心力衰竭

被引：10

作者：

颜媛

张会亮

方华强

郑铭

程和平

张荣利

机构：

[1] 北京大学分子医学研究所

来源：

生命科学 | 2008年 / 04期

关键词：

活性氧; 钙; 心力衰竭;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

100201 [内科学];

摘要：

活性氧信号和钙信号广泛存在于机体内,两者相互作用,共同参与调节机体多种生理功能及病理过程。本文对这两个信号系统之间的相互作用及相关机制、在心力衰竭过程中的作用及可能的临床应用前景进行了综述。

引用

页码：528 / 539

页数：12

共 31 条

[1]

What Cardiologists Should Know About Calcium Ion Channels and Their Regulation by Reactive Oxygen Species.[J].Livia C. Hool.Heart; Lung and Circulation.2007, 5

[2]

Vitamins C and E attenuate apoptosis, β-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction [J].

Qin, FZ ;

Yan, C ;

Patel, R ;

Liu, WM ;

Dong, ED .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (10) :1827-1842

[3]

Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure [J].

Yano, M ;

Okuda, S ;

Oda, T ;

Tokuhisa, T ;

Tateishi, H ;

Mochizuki, M ;

Noma, T ;

Doi, M ;

Kobayashi, S ;

Yamamoto, T ;

Ikeda, Y ;

Ohkusa, T ;

Ikemoto, N ;

Matsuzaki, M .

CIRCULATION, 2005, 112 (23) :3633-3643

[4]

Mitochondria-derived reactive oxygen species dilate cerebral arteries by activating Ca2+ sparks [J].

Xi, Q ;

Cheranov, SY ;

Jaggar, JH .

CIRCULATION RESEARCH, 2005, 97 (04) :354-362

[5]

Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release [J].

Jekabsone, A ;

Ivanoviene, L ;

Brown, GC ;

Borutaite, V .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2003, 35 (07) :803-809

[6]

Ca 2+ -induced oxidative stress in brain mitochondria treated with the respiratory chain inhibitor rotenone.[J].Solange C. Sousa;Evelise N. Maciel;Anibal E. Vercesi;Roger F. Castilho.FEBS Letters.2003, 1

[7]

Selegiline attenuates cardiac oxidative stress and apoptosis in heart failure: association with improvement of cardiac function.[J].Fuzhong Qin;Junya Shite;Weike Mao;Chang-seng Liang.European Journal of Pharmacology.2003, 2

[8]

The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model [J].