病毒性肝炎患者血清IL-12及IL-18水平变化的研究

被引：16

作者：

杜维波

许洁

甘建和

吴建成

于咸怀

机构：

[1] 滕州市中心人民医院

[2] 苏州大学附属第一医院

[3] 滕州市中心人民医院山东滕州

[4] 山东滕州

[5] 江苏苏州

来源：

临床肝胆病杂志 | 2002年 / 04期

关键词：

病毒性肝炎; 白细胞介素-12; 白细胞介素-18;

D O I：

暂无

中图分类号：

R512.6 [病毒性肝炎];

学科分类号：

100401 ;

摘要：

为探讨病毒性肝炎和肝炎后肝硬化患者血清中IL - 12、IL - 18的变化规律及其临床意义 ,应用ELISA法测定血清中IL - 12及IL - 18含量。各组肝炎及肝硬化患者IL - 12及IL - 18水平明显高于对照组 (P <0 0 0 1) ,以重型肝炎组水平最高。重型肝炎死亡病例IL - 12及IL - 18明显高于生存组 (P <0 0 1)。IL - 12和IL- 18与AST、ALT及TBil正相关 ,且IL - 12与CⅣ及HA水平正相关。IL - 12、IL - 18可能参与了病毒性肝炎和肝炎后肝硬化患者的肝脏炎性损伤过程 ,重型肝炎患者联合检测血清IL - 12及IL - 18有助于判断其预后。

引用

页码：215 / 216

页数：2

共 7 条

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