Th17细胞与银屑病

被引：14

作者：

常树霞 ^{[1
,2
]}

陈永锋 ^{[1
]}

机构：

[1] 广东省皮肤性病防治中心

[2] 广东医学院

来源：

皮肤性病诊疗学杂志 | 2010年 / 17卷 / 01期

关键词：

Th17细胞; 银屑病; IL-17;

D O I：

暂无

中图分类号：

R758.63 [牛皮癣（银屑病）];

学科分类号：

100206 ;

摘要：

Th17细胞是近年来发现的一种新型的CD4+T辅助细胞,它不同于经典的Th1和Th2细胞,有其独立的分化途径,表达控制其分化的独特转录因子——孤独受体。它通过分泌IL-17、IL-22等细胞因子发挥作用,现已证实其在防御胞外菌感染、介导慢性炎症、自身免疫病和肿瘤发病中发挥重要作用。本文就Th17细胞与银屑病的关系作一综述,期望可以对银屑病的发病机制有更进一步的认识。

引用

页码：71 / 74

页数：4

共 10 条

[1] Th效应细胞家族的新成员——Th17 [J].

李佳 ;

陈小平 .

中国免疫学杂志, 2007, (11) :1048-1051

[2] 寻常型银屑病患者皮损中白介素-22和S100A7,A8,A9mRNA的表达及关系 [J].

黄琨 ;

刘厚君 ;

涂亚庭 .

中国皮肤性病学杂志, 2007, (03) :138-140

[3] IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation [J].

Ma, Hak-Ling ;

Liang, Spencer ;

Li, Jing ;

Napierata, Lee ;

Brown, Tom ;

Benoit, Stephen ;

Senices, Mayra ;

Gill, Davinder ;

Dunussi-Joannopoulos, Kyriaki ;

Collins, Mary ;

Nickerson-Nutter, Cheryl ;

Fouser, Lynette A. ;

Young, Deborah A. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (02) :597-607

[4] Interleukin-17 as an effector molecule of innate and acquired immunity against infections [J].

Matsuzaki, Goro ;

Umemura, Masayuki .

MICROBIOLOGY AND IMMUNOLOGY, 2007, 51 (12) :1139-1147

[5] Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis [J].

Capon, Francesca ;

Di Meglio, Paola ;

Szaub, Joanna ;

Prescott, Natalie J. ;

Dunster, Christina ;

Baumber, Laura ;

Gutin, Alexander ;

Abkevic, Victor ;

Burden, A. David ;

Lanchbury, Jerry ;

Barker, Jonathan N. ;

Trembath, Richard C. ;

Nestle, Frank O. .

HUMAN GENETICS, 2007, 122 (02) :201-206

[6]

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties[J] . Casey T. Weaver,Laurie E. Harrington,Paul R. Mangan,Maya Gavrieli,Kenneth M. Murphy.Immunity . 2006 (6)

[7] The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells [J].

Ivanov, Ivaylo I. ;

McKenzie, Brent S. ;

Zhou, Liang ;

Tadokoro, Carlos E. ;

Lepelley, Alice ;

Lafaille, Juan J. ;

Cua, Daniel J. ;

Littman, Dan R. .

CELL, 2006, 126 (06) :1121-1133

[8] Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1 [J].

Koenders, MI ;

Lubberts, E ;

Oppers-Walgreen, B ;

van den Bersselaar, L ;

Helsen, MM ;

Di Padova, FE ;

Boots, AMH ;

Gram, H ;

Joosten, LAB ;

van den Berg, WB .

AMERICAN JOURNAL OF PATHOLOGY, 2005, 167 (01) :141-149

[9] Interleukin-12 p40 gene (IL12B) 3′-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris [J].

Tsunemi, Y ;

Saeki, H ;

Nakamura, K ;

Sekiya, T ;

Hirai, K ;

Fujita, H ;

Asano, N ;

Kishimoto, M ;

Tanida, Y ;

Kakinuma, T ;

Mitsui, H ;

Tada, Y ;

Wakugawa, M ;

Torii, H ;

Komine, M ;

Asahina, A ;

Tamaki, K .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2002, 30 (02) :161-166

[10]

large-scale genetic association study confirms IL12B and leads to the identification of II23R as psoriasis-risk genes .2 Cargill M,Schrodi SJ,Chang M.et al. Am J Hum Genet . 2007

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