G蛋白α亚基mRNA在不同甲状腺疾病的表达

被引：13

作者：

吕朝晖

陆菊明

潘长玉

罗国春

机构：

[1] 解放军总医院内分泌科,解放军总医院内分泌科,解放军总医院内分泌科,广东省深圳市第二人民医院北京,北京,北京

来源：

中华内科杂志 | 2003年 / 02期

关键词：

GTP结合蛋白质类; 甲状腺; 基因表达;

D O I：

暂无

中图分类号：

R581 [甲状腺疾病];

学科分类号：

摘要：

目的　观察G蛋白α亚基mRNA在不同甲状腺疾病的表达。方法　收集手术切除的甲状腺组织包括Graves病 5例、结节性甲状腺肿 7例、正常功能甲状腺腺瘤 6例和甲状腺乳头状癌 5例 ,以腺瘤周围组织作为正常甲状腺组织对照 ,观察刺激性G蛋白 (Gs)和抑制性 (Gi)α亚基的表达。结果　 (1 )GsαmRNA的表达 :甲状腺乳头状癌 (1 67± 0 2 5)较正常甲状腺组织 (1 1 0± 0 1 4 )和结节性甲状腺肿 (0 96± 0 31 )明显增高 (P <0 0 5和P <0 0 1 ) ,Graves病 (1 47± 0 1 1 )和正常功能甲状腺腺瘤 (1 36± 0 2 8)均显著高于结节性甲状腺肿 (P <0 0 5) ,但与正常甲状腺组织表达水平相似 ;(2 )Giα 2mRNA的表达 :Graves病显著低于结节性甲状腺肿 (0 68± 0 2 6比 1 1 5± 0 35 ,P <0 0 5) ;(3)Giα 1和Giα 3mRNA在不同甲状腺疾病的表达相似。结论　Gs蛋白α亚基的高表达可能在甲状腺乳头状癌的发病中起重要作用 ,不同疾病时甲状腺G蛋白α亚基具有不同的表达水平

引用

页码：34 / 36

页数：3

共 13 条

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