5-氟尿嘧啶毫微型胶囊的研究

被引：10

作者：

潘卫三

胡晋

机构：

[1] 沈阳药学院

[2] 沈阳药学院沈阳

[3] 沈阳

来源：

药学学报 | 1991年 / 04期

关键词：

5-氟尿嘧啶; 毫微型胶囊; 氰基丙烯酸正丁酯; 抗癌活性;

D O I：

10.16438/j.0513-4870.1991.04.008

中图分类号：

学科分类号：

摘要：

用氰基丙烯酸正丁酯制备了毫微型胶囊——抗癌药物新剂型。以5-氟尿嘧啶为模型药物所制得的毫微囊最大粒子直径为338nm。建立了凝胶色谱法测定包封率的新方法,5-氟尿嘧啶的包封率达40.9%。通过小鼠尾静脉注射,测得氰基丙烯酸正丁酯的LD_(50=267.7 mg/kg。制成毫微囊后,5-氟尿嘧啶对S180,Hep S以及EAC的抗癌活性明显提高。

引用

页码：280 / 285

页数：6

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