阿利克仑对1型糖尿病大鼠氧化应激的影响

被引：2

作者：

赵文来 ^{[1
]}

李晓珍 ^{[2
]}

黄进 ^{[1
]}

黄艳 ^{[2
]}

季勇 ^{[2
]}

机构：

[1] 南京市胸科医院心内科

[2] 南京医科大学动脉粥样硬化研究中心

来源：

南京医科大学学报(自然科学版) | 2011年 / 31卷 / 03期

关键词：

阿利克仑; 1型糖尿病; 氧化应激;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

目的:研究阿利克仑,一种直接的肾素抑制剂,对1型糖尿病大鼠模型氧化应激的影响。方法:SD大鼠随机分为4组(9只/组):对照组(CON),阿利克仑[30 mg/(kg.day)]处理对照组(C+A),糖尿病组(DM),阿利克仑[30 mg/(kg.day)]处理糖尿病组(D+M)。每天灌胃给药5周后,比较各组间改善效果。结果:与CON组比较,DM组血清中黄嘌呤氧化酶(XOD)活力增强(P<0.01),血清一氧化氮(NO)浓度升高(P<0.01),主动脉上活性氧增多;与DM组比较,阿利克仑处理(D+A)正常化这些数据(P<0.05)。阿利克仑处理不改变DM组减轻的体重(P<0.01)、增高的血糖和糖化血红蛋白水平(P<0.001)。结论:阿利克仑这种新型的直接肾素抑制剂可提高1型糖尿病大鼠抗氧化能力,抑制氧化应激。

引用

页码：391 / 394

页数：4

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