子宫内膜异位症患者腹腔液在不孕中的作用

被引:4
作者
王琳
史常旭
机构
[1] 第三军医大学附属西南医院妇产科
[2] 第三军医大学附属西南医院妇产科 重庆
[3] 重庆
关键词
子宫内膜异症; 不孕症; 腹腔液; 精子; 顶体反应白细胞介素1β;
D O I
10.16016/j.1000-5404.2002.01.043
中图分类号
R711.71 [子宫内膜异位症];
学科分类号
100211 ;
摘要
目的 探讨子宫内膜异位症 (EM)患者腹腔液对精子功能的影响及腹腔液中白细胞介素 1 β(IL 1 β)在不孕机制中的作用。方法 经腹腔镜检查确诊的子宫内膜异位症不孕患者共 2 0例 ,对照组 1 0例均为已生育妇女。在腹腔镜直视下或剖腹术时抽取腹腔液与精子孵育。同时采用放射免疫法检测腹腔液中IL 1 β含量。结果 EM组腹腔液与精子孵育 1 6h后 ,EM组精子顶体反应发生率显著低于对照组。EM组腹腔液中IL 1 β检出率为 1 0 0 % ,范围为 0 1 1~ 0 .2 7ng ml,均值为 (0 1 6± 0 0 5)ng ml;对照组检出率为 50 % ,范围为 0~ 0 1 6ng ml,均值为 (0 0 6± 0 2 8)ng ml,EM组显著高于对照组。结论 EM患者腹腔液抑制正常精子顶体反应 ,腹腔液中IL 1 β含量显著升高 ,可能与不孕有一定关系。
引用
收藏
页码:100 / 102
页数:3
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