他汀类药对脑梗死的临床疗效和作用机制

被引：34

作者：

张利军

白宇

机构：

[1] 上海中医药大学附属普陀医院神经内科

来源：

中国临床神经科学 | 2008年 / 02期

关键词：

缺血性脑卒中; 他汀类药; 治疗;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

多项研究已经提示他汀类药可以降低缺血性脑卒中发生率,具有神经保护作用。他汀类药除降血脂作用外,还有改善血管内皮功能,减少氧化应激,抑制炎性反应等作用。缺血性脑卒中患者使用他汀类药治疗后恢复较好,这不仅归因于他汀类药的调脂作用,其还有各种非降脂作用,称他汀类药具有多效性。本文总结了有关他汀类药多效性作用的实验研究,以及他汀类药预防缺血性脑卒中的临床试验研究。

引用

页码：217 / 221

页数：5

共 19 条

[1] Statin enhancement of collateralization in acute stroke [J].

Ovbiagele, B. ;

Saver, J. L. ;

Starkman, S. ;

Kim, D. ;

Ali, L. K. ;

Jahan, R. ;

Duckwiler, G. R. ;

Vinuela, F. ;

Pineda, S. ;

Liebeskind, D. S. .

NEUROLOGY, 2007, 68 (24) :2129-2131

[2] Prior statin use may be associated with improved stroke outcome after tissue plasminogen activator [J].

Alvarez-Sabin, Jose ;

Huertas, Rafael ;

Quintana, Manolo ;

Rubiera, Marta ;

Delgado, Pilar ;

Ribo, Marc ;

Molina, Carlos A. ;

Montaner, Joan .

STROKE, 2007, 38 (03) :1076-1078

[3] Acute neurovascular unit protection by simvastatin in transient cerebral ischemia [J].

Nagaraja, Tavarekere N. ;

Knight, Robert A. ;

Croxen, Richard L. ;

Konda, Kirthi P. ;

Fenstermacher, Joseph D. .

NEUROLOGICAL RESEARCH, 2006, 28 (08) :826-830

[4]

Influence of Atorvastatin Treatment on l-Arginine Cerebrovascular Reactivity and Flow-Mediated Dilatation in Patients With Lacunar Infarctions[J] . Janja Pretnar-Oblak,Miso Sabovic,Miran Sebestjen,Tomaz Pogacnik,Marjan Zaletel.Stroke . 2006 (10)

[5] Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes [J].

Wang, Sophia ;

Lee, Sun-Ryung ;

Guo, Shu-Zhen ;

Kim, Woo Jean ;

Montaner, Joan ;

Wang, Xiaoying ;

Lo, Eng H. .

STROKE, 2006, 37 (07) :1910-1912

[6]

MRI of combination treatment of embolic stroke in rat with rtPA and atorvastatin[J] . Guangliang Ding,Quan Jiang,Lian Li,Li Zhang,Zheng G. Zhang,Swayamprava Panda,James R. Ewing,Michael Chopp.Journal of the Neurological Sciences . 2006 (1)

[7]

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Council on Stroke: Co-Sponsored by the Council on Cardiovascular Radiology and Intervention: The American Academy of Neurology affirms the value of this guideline[J] . Ralph L. Sacco,Robert Adams,Greg Albers,Mark J. Alberts,Oscar Benavente,Karen Furie,Larry B. Goldstein,Philip Gorelick,Jonathan

[8] Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat [J].