甲醛对从业工人外周血淋巴细胞的遗传学效应

被引：10

作者：

金复生

朱瑞娟

机构：

[1] 上海医科大学金山医院职业医学研究室,上海医科大学金山医院职业医学研究室上海,上海

来源：

中华劳动卫生职业病杂志 | 1992年 / 05期

关键词：

脂质过氧化; 自由基; 肝损害; 黄磷; 四氯化碳;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

甲醛(FA)是一种诱变剂,同时也是一种人类的可疑致癌剂。在多种体外诱变试验中都得到了阳性结果,在啮齿动物中,FA可以引起鼻腔部和鼻咽部癌。对上海石化总厂生产过程中接触FA的21名男性工人进行了染色体分析,14名非生产工人作为对照。FA生产环境中的空气浓度年平均为2.51mg/m3。结果与对照组比较,SCE没有显著改变,而染色体的畸变率明显高于对照组(P<0.05)。畸变类型包括单体型和染色体型两种,主要是单体断裂、无着丝点断片、双着丝点和非整倍体。证明FA是一种染色体断裂剂。我国1979年颁发的FA空气中最高容许浓度3mg/m3对长期职业接触FA的人群而言,仍是不安全的。

引用

页码：277 / 278+281 +281-320

页数：5

共 8 条

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