儿童EB病毒感染的免疫功能状况

被引：44

作者：

曾宾

肖燕

金润铭

赵方

林雯

聂李平

机构：

[1] 华中科技大学同济医学院附属协和医院儿科

来源：

实用儿科临床杂志 | 2006年 / 22期

关键词：

EB病毒; 传染性单核细胞增多症; CD4+; CD8+; CD23+; T淋巴细胞; B细胞;

D O I：

暂无

中图分类号：

R725.1 [小儿传染病];

学科分类号：

摘要：

目的研究EB病毒(EBV)感染儿童免疫功能状况及其与临床和预后的关系。方法用流式细胞仪(FCM)分别对30例传染性单核细胞增多症(IM)患儿急性期、恢复期外周血淋巴细胞CD3+、CD4+、CD8+、CD19+、CD23+抗原进行检测,并与20例同龄健康对照组儿童比较。结果IM患儿急性期CD4+、CD8+、CD19+、CD23+淋巴细胞百分率分别为(14.88±3.14)%,(65.49±5.33)%,(5.70±2.89)%,(2.41±1.83)%,恢复期为(36.75±3.88)%,(41.64±5.11)%,(15.98±2.80)%,(5.02±2.76)%。急性期CD8+明显高于恢复期和对照组,而CD4+、CD19+、CD23+淋巴细胞明显低于恢复期和对照组。恢复期3例CD23+细胞比值较高。结论EBV感染儿童外周血淋巴细胞亚群明显异常,CD23+细胞的持续增高与CD4+T细胞的长期低下有可能成为评价IM预后的指标。

引用

页码：1549 / 1550

页数：2

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