人t-PA溶栓突变体的研究进展

被引：4

作者：

赵月峨

机构：

[1] 北京微生物流行病研究所北京

来源：

生物技术通讯 | 2002年 / 04期

关键词：

t-PA突变体; 溶栓;

D O I：

暂无

中图分类号：

R346 [];

学科分类号：

1001 ;

摘要：

人t-PA在机体循环中的纤溶系统中起重要作用,是一种内源性溶血栓因子,t-PA蛋白分子可直接用于溶栓治疗。但天然的t-PA分子在体内半衰期短、极易被清除,因而限制其广泛应用。根据它的结构特点而改造的一系列t-PA变体分子将成为新一代溶栓药物,在溶栓治疗中广泛应用。

引用

页码：305 / 307

页数：3

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