甲基强的松龙对脑缺血后纹状体内TNFα、NO含量的影响

被引:2
作者
李伟
吕传真
机构
[1] 复旦大学医学院神经病学研究所
关键词
脑缺血; 甲基强的松龙; 一氧化氮; 肿瘤坏死因子α;
D O I
暂无
中图分类号
R741.02 [神经病理学、病因学];
学科分类号
0710 ; 071006 ;
摘要
目的:观察甲基强的松龙对局灶性脑缺血模型纹状体内TNFα、NO含量的影响。方法:用线栓法制备局灶性脑缺血模型,用ELISA方法检测TNFα,采用Griess试剂测定微透析液中NO的代谢产物亚硝酸盐含量。结果:缺血1h再灌注6h,缺血侧纹状体内NO及TNFα含量升高,给予3mg·kg-1甲基强的松龙,可以使两种物质的含量下降。结论:给予小剂量的甲基强的松龙(3mg·kg-1)可以降低脑缺血组织的TNFα、NO含量,可能对脑缺血损伤产生保护作用。
引用
收藏
页码:181 / 183
页数:3
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