伴随病影响老年高血压患者认知功能和日常生活能力

被引:8
作者
卫炜 [1 ]
陆惠华 [1 ]
金贤 [1 ]
陈启稚 [2 ]
方宁远 [1 ]
机构
[1] 上海第二医科大学附属仁济医院老年病科
[2] 上海第九人民医院
关键词
高血压; 糖尿病; 高脂血症; 认知功能; 日常生活能力;
D O I
10.16439/j.cnki.1673-7245.2005.12.010
中图分类号
R749.1 [脑器质性精神障碍];
学科分类号
100205 ;
摘要
目的探讨老年高血压患者中冠心病、脑卒中、糖尿病、高脂血症等因素与认知功能和日常生活质量的相关性。方法常规体检中随机抽查60~93岁老年人542名[平均年龄(73.6±6.8)岁],其中男性:494例;女性:48例,检测血压、血糖和血脂,同时进行简易精神状况量表(MMSE)和日常生活能力(ADL)的测试,将所得结果用SAS6.12版统计软件分析。结果结果显示高血压组321例(59.2%),非高血压组221例(40.8%)。高血压组中合并冠心病125例(38.9%)、合并脑中风60例(18.7%)、合并高脂血症193例(60.1%)、合并糖尿病88例(27.4%)、联合合并高脂血症与糖尿病58例(18.1%),以合并冠心病、脑卒中、糖尿病较非高血压组明显增多(P<0.01)。高血压组ADL成绩(23.3±7.9)明显高于非高血压组(21.6±4.7)(P<0.05),两组MMSE评分无差异。高血压按是否合并糖尿病、高脂血症分组后进行认知功能评分,高血压并存高脂血症组MMSE成绩(28.4±1.6)最高,高血压并存糖尿病组MMSE成绩(25.3±2.7)(P<0.01)、高血压同时合并糖尿病、高脂血症组MMSE成绩(27.0±2.5)明显降低(P<0.05),但以单纯合并糖尿病组下降最显著。结论用MMSE法评估老年高血压与非高血压组发现两组认知功能状况无显著差异。日常生活能力降低,可能与高血压者心、脑血管意外事件并发率高有关。老年高血压并存糖尿病认知功能明显降低,提示糖尿病是影响认知功能的独立危险因素。并存高脂血症者降脂治疗对认知功能有改善。
引用
收藏
页码:779 / 782
页数:4
相关论文
共 14 条
[1]  
Bodovitz S,Klein WL.Cholesterol modulates-αsecretase leav-age of amyloid precursor protein. Journal of Biological Chemistry . 1996
[2]  
Tzourio L,Dufouil L,Ducimetiere P,et al.A congnitive de-cline in individuals with high blood pressure:A longitudinalstudy in the elderly. Neurology . 1999
[3]  
Knopman D,Boland LL,Mosley T,et al.Cardiovascular riskfactors and cognitive decline in middle-aged adults. Neurology . 2001
[4]  
Kivipelto M,Helkala EL,Hanninen T,et al.Midlife vascularrisk factors and late-life mild cognitive impairment:A popula-tion-based study. Neurology . 2001
[5]  
Strassburger TL,Lee HC,Daly EM,et al.Interactive effectsof age and hypertension on volumes of brain structures. Stroke . 1997
[6]  
Van Swieten JC,Geyskes GG,Derix MM,et al.Hypertensionin the elderly is associated wth white matter lesions and congni-tive decline. American Journal of Neuroradiology . 1991
[7]  
Van Boxtel MPJ,Gaillard C,Houx PJ,et al.Can the bloodpressure predict task performance in a healthy population sample. Journal of Hypertension . 1997
[8]  
Hassing LB,Hofer SM,Nilsson SE,et al.Comorbid type 2 di-abetes mellitus and hypertension exacerbates cognitive decline:evidence from a longitudinal study. Age and Ageing . 2004
[9]  
Stewart R,Richards M,Brayne C,et al.Vascular risk and cog-nitive impairment in an older,British,African-Caribbean popu-lation. Journal of the American Geriatrics Society . 2001
[10]  
Kahonen-vare M,Brunni-Hakala S,Lindroos M,et al.Leftventricular hypertrophy and blood pressure as predictors of cog-nitive decline in old age. Aging Clinical and Experimental Research . 2004