人神经生长因子治疗糖尿病性多发性神经病的随机双盲研究

被引：5

作者：

张云云

苏雅茹

杨莉芹

蒋雨平

机构：

[1] 复旦大学附属华山医院神经内科

来源：

中国临床神经科学 | 2003年 / 01期

关键词：

人神经生长因子; 糖尿病性多发性神经病; 双盲研究;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

摘要：

目的:观察人神经生长因子(hNGF)治疗糖尿病性多发性神经病(DPN)的有效性及安全性。方法:采用双盲随机对照研究,48例DPN病人随机分为2组:hNGF组24例,每日给予hNGF 4 mL(1000 u),肌注:对照组 24例,每日给予安慰剂 4 mL,肌注,疗程均为12周。结果:hNGF组治疗12周后,患者MDNS和自觉感觉障碍有效率分别为73.83％和83.33％,明显高于安慰剂组。治疗结束后4及12周,其有效率仍显著高于对照组。治疗期间未发现严重不良反应。结论:hNGF治疗DPN有效且安全。

引用

页码：67 / 70

页数：4

共 9 条

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