MAPK途径在阿尔茨海默病发病机制中的作用

被引：7

作者：

陈燕华 ^{[1
]}

严丽荣 ^{[2
]}

机构：

[1] 江苏大学临床医学院

[2] 江苏大学附属医院老年病科

来源：

实用老年医学 | 2011年 / 25卷 / 05期

关键词：

丝裂原活化蛋白激酶; 信号转导途径; AD; 神经元; 神经组织; MAPK; 阿尔茨海默病; 过磷酸化;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

<正>阿尔茨海默病(Alzheimer's disease,AD)是老年痴呆最常见病因。临床以老年斑(senile plaques,SP)和神经纤维缠结(neurofibrillary tangles,NFTs)为特征,其病理变化以细胞外β淀粉样蛋白(β-amyloid,Aβ)沉积导致SP的形成及细胞内自我聚集的高度磷酸

引用

页码：431 / 434

页数：4

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