喉癌中环氧化酶-2和p53的表达及相关性研究

被引：4

作者：

鲁海涛

龚树生

机构：

[1] 华中科技大学同济医学院附属协和医院耳鼻咽喉科,华中科技大学同济医学院附属协和医院耳鼻咽喉科武汉,,现在荆州市中心医院耳鼻咽喉科,湖北荆州,,武汉,

来源：

临床耳鼻咽喉科杂志 | 2004年 / 07期

关键词：

喉肿瘤; 环氧化酶-2; 蛋白质p53;

D O I：

暂无

中图分类号：

R739.65 [喉肿瘤];

学科分类号：

摘要：

目的 :了解喉癌组织中环氧化酶 2 (Cox 2 )及p5 3的表达 ,探讨Cox 2在喉癌发生发展中的作用及与p5 3之间的关系。方法 :采用免疫组织化学方法检测 6 3例喉癌组织中Cox 2与 p5 3的表达情况。结果 :6 3例喉癌标本中Cox 2阳性表达率为 5 8.7% (37/6 3) ,患者的不同临床分期的表达差异有统计学意义 (P <0 .0 5 )。p5 3的阳性表达率为 6 3.5 % (4 0 /6 3) ,不同组织病理学分级的 p5 3阳性表达的差异有统计学意义 (P <0 .0 5 ) ;Cox 2与p5 3之间存在等级相关性。结论 :Cox 2能促进喉癌的生长、增殖与浸润 ,应用Cox 2抑制剂可望对喉癌的发展起到抑制作用

引用

页码：421 / 423

页数：3

共 7 条

[1]

Cyclooxygense-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Chan G,Boyle J O,Yang E K,et al. Cancer Research . 1999

[2]

Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. Costa C,Soares R,Reis-Filho JS,et al. Journal of Clinical Pathology . 2002

[3]

Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions. Sung J J,Leung W K,Go M Y,et al. American Journal of Pathology . 2000

[4]

Inhibition of cyclooxygenase-2 suppress angiogenesis and the growth of prostate cancer in vivo. Liu X H,Kirschenbaum A,Yao S,et al. Journal d Urologie . 2000

[5]

Tumor invasivense and liver metastasis of colon cancer cells correlated with cyclooxygenase 2 (Cox-2)expression and inhibitor by a Cox2-selective inhibitor, etodoliac. Chen W S,Wei S J,Liu J M,et al. International Journal of Cancer . 2001

[6]

Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogensis in human gastric cancer. Uefuji K,Ichikura T,Mochizuki H,et al. Clinical Cancer Research . 2000

[7]

Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. Eli Y,Przedecki F,Levin G,et al. Biochemical Pharmacology . 2001

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