兔脊髓分级缺血-再灌注损伤对体感诱发电位的影响

被引：7

作者：

方华

王泉云

李昌熙

刘进

机构：

[1] 四川大学华西医院麻醉科

来源：

中国胸心血管外科临床杂志 | 2007年 / 04期

基金：

高等学校博士学科点专项科研基金;

关键词：

脊髓保护; 缺血-再灌注损伤; 体感诱发电位;

D O I：

暂无

中图分类号：

R651.2 [脊髓];

学科分类号：

100223 [神经外科学];

摘要：

目的了解不同程度脊髓缺血-再灌注损伤与体感诱发电位(SEP)、神经功能评分及脊髓病理改变的关系。方法将40只新西兰大耳白兔随机均分为4组,假手术组、缺血30min组、缺血45min组和缺血60min组。采用腹主动脉阻断法建立兔脊髓缺血-再灌注损伤模型,分别于缺血前、缺血5、10min、再灌注15、30min、1、2、24和48h监测SEP。于再灌注6、12、24和48h进行神经功能评分,再灌注48h进行脊髓病理学观察。结果阻断腹主动脉血流30、45和60min后开放分别表现为轻、中、重度缺血-再灌注损伤脊髓的病理学改变特点。脊髓轻度缺血-再灌注损伤中SEP波幅和潜伏期分别于再灌注15和30min时恢复至缺血前水平(P>0.05);脊髓中度缺血-再灌注损伤中SEP波幅和潜伏期分别于再灌注30min和再灌注1h恢复至缺血前水平(P>0.05);脊髓重度缺血-再灌注损伤中SEP波幅和潜伏期分别明显下降和延长,与其他各组组间比较差异有统计学意义(P<0.01)。各组神经功能评分组间比较差异均有统计学意义(P<0.01)。结论脊髓缺血-再灌注损伤中SEP波幅较潜伏期恢复迅速。术中SEP监测能够敏感而准确地反映缺血-再灌注损伤中脊髓功能的变化,可为临床应用提供实验依据。

引用

收藏

页码：280 / 284

页数：5

相关论文

共 11 条

[1]

Effects of general anesthesia on high-frequency oscillations in somatosensory evoked potentials [J].

Urasaki, Eiichirou ;

Genmoto, Tetsuya ;

Yokota, Akira ;

Maeda, Rieko ;

Akamatsu, Naoki .

JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2006, 23 (05) :426-430

[2]

Postconditioning, a series of brief interruptions of early reperfusion, prevents neurologic injury after spinal cord ischemia [J].

Jiang, Xiaojing ;

Shi, Enyi ;

Nakajima, Yoshiki ;

Sato, Shigehito .

ANNALS OF SURGERY, 2006, 244 (01) :148-153

[3]

Neurological aspects of spinal-cord repair: promises and challenges [J].

Dietz, Volker ;

Curt, Armin .

LANCET NEUROLOGY, 2006, 5 (08) :688-694

[4]

Functional imaging with Laser Speckle Contrast Analysis: Vascular compartment analysis and correlation with Laser Doppler Flowmetry and somatosensory evoked potentials.[J].Georg Royl;Christoph Leithner;Heike Sellien;Jan Philipp Müller;Dirk Megow;Nikolas Offenhauser;Jens Steinbrink;Matthias Kohl-Bareis;Ulrich Dirnagl;Ute Lindauer.Brain Research.2006, 1

[5]

Perioperative management to improve neurologic outcome in thoracic or thoracoabdominal aortic stent-grafting [J].

Weigang, Ernst ;

Hartert, Marc ;

Siegenthaler, Michael P. ;

Beckmann, Nicholas A. ;

Sircar, Ronen ;

Szabo, Gabor ;

Etz, Christian D. ;

Luehr, Maximilian ;

von Samson, Patrick ;

Beyersdorf, Friedhelm .

ANNALS OF THORACIC SURGERY, 2006, 82 (05) :1679-1687

[6]

Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism [J].

Reece, T. Brett ;

Kron, Irving L. ;

Okonkwo, David O. ;

Laurent, Jeffrey J. ;

Tache-Leon, Carlos ;

Maxey, Thomas S. ;

Ellman, Peter I. ;

Linden, Joel ;

Tribble, Curtis G. ;

Kern, John A. .

JOURNAL OF VASCULAR SURGERY, 2006, 44 (02) :392-397

[7]

Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation [J].

Moon, L. D. F. ;

Leasure, J. L. ;

Gage, F. H. ;

Bunge, M. B. .

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, 2006, 24 (03) :147-161

[8]

Intraoperative Monitoring of Segmental Spinal Nerve Root Function with Free-Run and Electrically-Triggered Electromyography and Spinal Cord Function with Reflexes and F-Responses.[J].Ronald E. Leppanen.Journal of Clinical Monitoring and Computing.2006, 6

[9]

Critical analysis of outcome determinants affecting repair of intact aneurysms involving the visceral aorta [J].

Back, MR ;

Bandyk, M ;

Bradner, M ;

Cuthbertson, D ;

Johnson, BL ;

Shames, ML ;

Bandyk, DF .

ANNALS OF VASCULAR SURGERY, 2005, 19 (05) :648-656

[10]

Surgical repair of thoracoabdominal aneurysms: patient selection, techniques and results [J].

Gloviczki, P .

CARDIOVASCULAR SURGERY, 2002, 10 (04) :434-441