糖尿病肾病肾小球硬化的机制研究进展

被引:15
作者
于牧鑫
解汝娟
机构
[1] 哈尔滨医科大学附属第一医院肾内科
关键词
糖尿病肾病; 肾小球硬化; 微粒; 细胞外染色质;
D O I
暂无
中图分类号
R587.2 [糖尿病性昏迷及其他并发症]; R692 [肾疾病];
学科分类号
100201 [内科学]; 100221 [泌尿外科学];
摘要
肾小球硬化是糖尿病肾病(DKD)病情进展的重要原因。血糖、血脂以及炎症紊乱是DKD的临床特点,这些因素均可引起DKD肾脏损伤。此外,外周血细胞释放的微粒、中性粒细胞释放的胞外染色质、激活的蛋白C、血栓调节蛋白调节的补体系统以及微RNA的变化会影响肾小球基膜的内皮细胞、足细胞以及系膜细胞的功能,并且增加纤维蛋白与补体复合物沉积在肾小球内的沉积,加速肾小球的损伤以及纤维化和硬化。了解DKD肾小球损伤的机制对于DKD的治疗有着重要意义。
引用
收藏
页码:3632 / 3636
页数:5
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