抑郁症大鼠海马BDNF及其受体TrkB和p75NTR的表达及米氮平的调节作用

被引：2

作者：

董玉霞 ^{[1
,2
]}

孙晓红 ^{[1
,2
]}

何悦 ^{[1
,2
]}

杨洋 ^{[1
,2
]}

姜源 ^{[1
,2
]}

马超 ^{[1
,2
]}

刘晓楠 ^{[1
,2
]}

李慧源 ^{[1
,2
]}

机构：

[1] 中国医科大学附属第四医院神经内科

[2] 中国医科大学盛京医院集团抚顺医院

来源：

脑与神经疾病杂志 | 2014年 / 03期

关键词：

慢性应激抑郁; 海马; 脑源性神经营养因子; 酪氨酸激酶受体B; 神经营养因子低亲和力受体;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

目的观察抑郁症模型大鼠学习记忆力改变情况,研究海马脑源性神经营养因子(BDNF)、酪氨酸激酶受体B(TrkB)和神经营养因子低亲和力受体(p75NTR)蛋白的表达变化,以及米氮平的调节作用。方法制备抑郁症大鼠模型;采用Morris水迷宫实验方法记录大鼠游动距离变化;免疫组化染色方法测定海马BDNF、TrkB和p75NTR表达阳性区吸光度值。结果抑郁症模型大鼠在目标象限游动距离减少,海马BDNF及TrkB蛋白表达减少,p75NTR蛋白表达增加;米氮平逆转上述行为学异常及蛋白表达异常(p﹤0.01)。结论抑郁症模型大鼠可能存在BDNF-p75NTR通路信息传递增强,而抗抑郁治疗用药可能通过BDNFTrkB信号通路的改变引起相应行为学改善。

引用

页码：161 / 164

页数：4

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