正常血清转氨酶浓度与肝病死亡率危险性的关系:前瞻性队列研究

被引：5

作者：

Hyeon Chang Kim

Chung Mo Nam

Sun Ha Jee

Kwang Hyub Han

Dae Kyu Oh

Il Suh

邓瑞雪

机构：

[1] DepartmentofPreventiveMedicineandPublicHealth,YonseiUniversityCollegeofMedicine,Shinchon-Dong,Seodaemun-Gu,Seoul-,RepublicofKorea,instructor,DepartmentofPreventiveMedicineandPublicHealth,YonseiUniversityCollegeofMedicine,Shinchon-Dong,Seodaemun-Gu,Seoul-,R

来源：

英国医学杂志(中文版) | 2004年 / 05期

关键词：

血清转氨酶; 肝病; 死亡率; 危险性;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病];

学科分类号：

1002 ; 100201 ;

摘要：

目的研究正常范围的血清转氨酶浓度与肝病死亡率之间的关系。方法前瞻性队列研究研究场所韩国医疗保险公司,随访8年研究对象94 533例男性和47 522例女性,年龄35～59岁。主要结果评价根据死亡证明所获得的肝脏疾病死亡率。结果转氨酶浓度与肝脏疾病的死亡率有正相关,甚至正常范围内(35～40IU/l)也是如此。与浓度<20IU/l相比,谷草转氨酶的浓度为20～29IU/l和30～39IU/l时,调整后的相对危险性分别为男性为2.5(95％可信区间2.0～3.0)和8.0(6.6～9.8),女性为3.3(1.7～6.4)和18.2(8.1～40.4)。谷丙转氨酶相应的危险性分别为男性为2.9(2.4～3.5)和9.5(7.9～11.5),女性为3.8(1.9～7.7)和6.6(1.5～25.6)。根据受试者工作特性曲线,对于男性来说,谷草转氨酶和谷丙转氨酶预测肝脏疾病的最佳临界点分别为31IU/l及30IU/l。结论对于转氨酶活性轻度升高但仍在正常范围者,应密切观察并进一步进行肝脏疾病的检查。

引用

页码：280 / 283

页数：4

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