自噬在骨性关节炎中的研究进展

被引：20

作者：

赵旭

傅志俭

机构：

[1] 山东大学附属省立医院疼痛科

来源：

中国疼痛医学杂志 | 2017年 / 23卷 / 04期

关键词：

骨性关节炎; 软骨退变; 软骨细胞; 自噬;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨性关节炎(osteoarthritis,OA)以关节肿胀和疼痛为主要症状,严重影响患者生活质量,寻找治疗骨性关节炎有效药物成为当今研究热点。目前临床主要有:口服非甾体类抗炎药物,关节腔内注射玻璃酸钠等,以缓解疼痛,改善关节活动度的对症治疗,尚未发现有效治愈骨性关节炎的靶向药物。骨性关节炎的病理表现以滑膜炎和软骨退变为主。目前研究发现软骨细胞自噬水平下降是软骨退变原因之一,可能是治疗骨性关节炎药物靶点。该文就自噬定义、相关信号通路及影响因素,自噬在软骨细胞中的作用及骨关节炎中自噬等予以综述,为寻找有效治疗骨性关节炎药物提供新的思路。

引用

页码：241 / 244

页数：4

共 18 条

[1]

3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of α-synuclein in PC12 cells [J].

Xue, Danfeng ;

Wang, Quanxin ;

Chen, Ziheng ;

Cai, Lei ;

Bao, Li ;

Qi, Qiuyue ;

Liu, Lei ;

Wang, Xiaohui ;

Jin, Haijing ;

Wang, Jun ;

Wu, Hao ;

Liu, Hongwei ;

Chen, Quan .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (07) :1464-1470

[2]

Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis [J].

Mobasheri, Ali ;

Matta, Csaba ;

Zakany, Roza ;

Musumeci, Giuseppe .

MATURITAS, 2015, 80 (03) :237-244

[3]

Inhibition of the mTOR pathway: A possible protective role in coronary artery disease [J].

Tarantino, Giovanni ;

Capone, Domenico .

ANNALS OF MEDICINE, 2013, 45 (04) :348-356

[4]

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes [J].

Sasaki, Hiroshi ;

Takayama, Koji ;

Matsushita, Takehiko ;

Ishida, Kazunari ;

Kubo, Seiji ;

Matsumoto, Tomoyuki ;

Fujita, Norifumi ;

Oka, Shinya ;

Kurosaka, Masahiro ;

Kuroda, Ryosuke .

ARTHRITIS AND RHEUMATISM, 2012, 64 (06) :1920-1928

[5]

The Role of Atg Proteins in Autophagosome Formation.[J].Noboru Mizushima;Tamotsu Yoshimori;Yoshinori Ohsumi.Annual Review of Cell and Developmental Biology.2011, 1

[6]

Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model [J].

Almonte-Becerril, M. ;

Navarro-Garcia, F. ;

Gonzalez-Robles, A. ;

Vega-Lopez, M. A. ;

Lavalle, C. ;

Kouri, J. B. .

APOPTOSIS, 2010, 15 (05) :631-638

[7]

Autophagy Is a Protective Mechanism in Normal Cartilage, and Its Aging-Related Loss Is Linked With Cell Death and Osteoarthritis [J].

Carames, Beatriz ;

Taniguchi, Noboru ;

Otsuki, Shuhei ;

Blanco, Francisco J. ;

Lotz, Martin .

ARTHRITIS AND RHEUMATISM, 2010, 62 (03) :791-801

[8]

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix [J].

Loeser, R. F. .

OSTEOARTHRITIS AND CARTILAGE, 2009, 17 (08) :971-979

[9]

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy.[J].Yongjie Wei;Sophie Pattingre;Sangita Sinha;Michael Bassik;Beth Levine.Molecular Cell.2008, 6

[10]

臭氧对兔骨性关节炎关节软骨胶原影响的实验研究 [J].

岳惠忠 ;

陆巍 ;

沃春新 ;

姚旌 ;

王林 .

中国疼痛医学杂志, 2015, 21 (12) :899-902+907

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