血尿酸水平与急性脑梗死的预后

被引:19
作者
朱红凤 [1 ]
王爱明 [1 ]
张凤佳 [1 ]
韩杰 [1 ]
王哲 [1 ]
洪晓军 [2 ]
机构
[1] 大连医科大学附属第一医院神经内科
[2] 大连医科大学附属第一医院神经电生理室
关键词
尿酸; 高尿酸血症; 脑梗死; 一氧化氮; 预后;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
<正>中枢神经系统内存在黄嘌呤氧化酶系统,在急性脑梗死发作时,由于脑组织缺血、缺氧,启动黄嘌呤-黄嘌呤氧化酶等生化反应系统,产生大量尿酸及超氧阴离子等自由基,导致急性脑梗死患者血清尿酸水平较正常人明显升高。近几年流行病学及国内多数研究认为,高尿酸血症是急性脑梗死危险因素之一[1]。WHO在1989年将高尿酸血症确定为
引用
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页码:1003 / 1004
页数:2
相关论文
共 6 条
  • [1] Lack of association between serum uric acid levels and outcome in acute ischemic stroke[J] . Irene Miedema,Maarten Uyttenboogaart,Marcus Koch,Berry Kremer,Jacques de Keyser,Gert-Jan Luijckx.Journal of the Neurological Sciences . 2012 (1-2)
  • [2] Translational Stroke Research of the Combination of Thrombolysis and Antioxidant Therapy
    Amaro, Sergio
    Chamorro, Angel
    [J]. STROKE, 2011, 42 (05) : 1495 - 1499
  • [3] Serum Uric Acid and Risk of Cardiovascular Mortality: A Prospective Long-Term Study of 83 683 Austrian Men[J] . Ruttmann, Elfriede,Brant, Larry,Kelleher, Cecily,Klenk, Jochen,Concin, Hans,Diem, Günter,Pfeiffer, Karl,Ulmer, Hanno.Clinical Chemistry . 2008 (2)
  • [4] A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke
    Amaro, Sergio
    Soy, Dolors
    Obach, Victor
    Cervera, Alvaro
    Planas, Anna M.
    Chamorro, Angel
    [J]. STROKE, 2007, 38 (07) : 2173 - 2175
  • [5] Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: A prospective 21-year follow-up study[J] . Alexander M. Strasak,Cecily C. Kelleher,Larry J. Brant,Kilian Rapp,Elfriede Ruttmann,Hans Concin,Günter Diem,Karl P. Pfeiffer,Hanno Ulmer.International Journal of Cardiology . 2007 (2)
  • [6] Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes[J] . Edward J.Newman,Fariel S.Rahman,Kennedy R.Lees,Christopher J.Weir,Matthew R.Walters.Diabetes Metab. Res. Rev. . 2005 (1)