抗氧化药物防治噪声聋研究进展

被引：11

作者：

李艳华

刘移民

机构：

[1] 广州市职业病防治院广州市职业环境与健康效应实验室广州市医学重点学科职业健康监护科

来源：

中国职业医学 | 2015年 / 42卷 / 05期

关键词：

噪声聋; 噪声; 听力损失; 氧化应激; 抗氧化药物;

D O I：

暂无

中图分类号：

R135.8 [职业性耳聋];

学科分类号：

100402 ;

摘要：

<正>噪声包括妨碍人们正常休息、学习和工作的任何声音,它能引起人们烦躁,甚至危害人体健康,是现代社会中世界性的七大典型公害之一。2011年统计数据显示,我国有超过1 000万工人暴露于噪声作业环境中,其中数百万人患有不同程度的噪声性听力损失(NIHL)[1]。目前研究发现NIHL的致病机制主要有:1机械损伤;2血管学说;3代谢学说[2]。实验研究显示,抗氧化剂有助于恢复体内应激性的氧化还原失

引用

页码：579 / 581

页数：3

共 22 条

[1] 工作场所噪声致听力损失研究概况 [J].

宁康 ;

刘茁 ;

李丹 ;

何雅慧 ;

郭军巧 .

中国职业医学, 2011, 38 (06) :511-512

[2]

Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways[J] . Gajendra Kumar Azad,Raghuvir S. Tomar.Molecular Biology Reports . 2014 (8)

[3] The effect of resveratrol on the prevention of cisplatin ototoxicity [J].

Erdem, T. ;

Bayindir, Tuba ;

Filiz, A. ;

Iraz, M. ;

Selimoglu, E. .

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2012, 269 (10) :2185-2188

[4]

Efficacy of different routes of administration for Coenzyme Q10 formulation in noise-induced hearing loss: Systemic versus transtympanic modality[J] . Anna Rita Fetoni,Diana Troiani,Sara L. Eramo,Rolando Rolesi,Gaetano Paludetti Troiani.Acta Oto-Laryngologica . 2012 (4)

[5]

Protective role of resveratrol against cisplatin induced ototoxicity in guinea pigs[J] . Ali Cemal Yumusakhuylu,Mine Yazici,Murat Sari,Adem Binnetoglu,Ebru Kosemihal,Ferda Akdas,Serap Sirvanci,Meral Yuksel,Cuneyd Uneri,Alper Tutkun.International Journal of Pediatric Otorhinolaryngology . 2011 (3)

[6]

Multifunctional Ebselen drug functions through the activation of DNA damage response and alterations in nuclear proteins[J] . Gajendra K. Azad,Shah Jaimin Balkrishna,Narayanan Sathish,Sangit Kumar,Raghuvir S. Tomar.Biochemical Pharmacology . 2011 (2)

[7]

d -methionine ( d -met) significantly rescues noise-induced hearing loss: Timing studies[J] . Kathleen Campbell,Alex Claussen,Robert Meech,Steven Verhulst,Daniel Fox,Larry Hughes.Hearing Research . 2011 (1)

[8]

N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers[J] . Cheng-Yu Lin,Jiunn-Liang Wu,Tung-Sheng Shih,Perng-Jy Tsai,Yih-Min Sun,Mi-Chia Ma,Yueliang L. Guo.Hearing Research . 2010 (1)

[9]

N -acetylcysteine attenuates noise-induced permanent hearing loss in diabetic rats[J] . Hung-Pin Wu,Chuan-Jen Hsu,Tsun-Jen Cheng,Yueliang Leon Guo.Hearing Research . 2010 (1)

[10]

Water-soluble Coenzyme Q 10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL)[J] . Anna Rita Fetoni,Roberto Piacentini,Antonella Fiorita,Gaetano Paludetti,Diana Troiani.Brain Research . 2008

← 1 2 3 →