载荷诱导骨生长的力学细胞生物学机制

被引:52
作者
张毅奕
陶祖莱
机构
[1] 中国科学院力学研究所!北京
关键词
力学细胞生物学; 应力与生长; 骨骼细胞; 信号转导;
D O I
暂无
中图分类号
Q66 [生物力学];
学科分类号
071011 [生物物理学];
摘要
骨骼的结构和功能在很大程度上依赖于其所处的力学环境,这一观点已被广为接受.自从Wolff提出其著名的骨转换定律以来,骨生长与载荷间的关系一直是生物力学中一个重要的问题.大量的动物实验均证明二者之间存在明确的关联.然而,载荷诱导骨生长的力学细胞生物学(mechanocy-tobiology)机制仍很不清楚.十余年来体外培养骨骼细胞加载的研究为应力(应变)诱导骨生长提供了一个微观理论框架.目前认为,载荷诱导骨生长的过程可分为四个环节,即:力学耦联、生物化学耦联、胞间信号转导和效应细胞反应.详细阐述了这几个环节,并就今后的研究方向作一讨论.
引用
收藏
页码:433 / 445
页数:13
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