生物制剂在类风湿关节炎中的应用与进展

被引:49
作者
郑文洁
曾小峰
机构
[1] 中国医学科学院北京协和医学院北京协和医院风湿免疫科,风湿免疫病学教育部重点实验室
关键词
生物制剂; 类风湿关节炎;
D O I
暂无
中图分类号
R593.22 [类风湿性关节炎];
学科分类号
100201 [内科学];
摘要
目的:介绍生物制剂在类风湿关节炎(rheumatoid arthritis,RA)中的应用及其最新研究进展。方法:根据近年来的相关文献和指南进行综述,对生物制剂在治疗RA中的作用机制、临床疗效和安全性等方面进行综述。结果和结论:生物制剂是一类安全、有效的药物,在控制风湿病情和改善生活质量方面发挥了重要作用,具有良好的临床应用前景。
引用
收藏
页码:1 / 7
页数:7
相关论文
共 7 条
[1]
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial [J].
Gabay, Cem ;
Emery, Paul ;
van Vollenhoven, Ronald ;
Dikranian, Ara ;
Alten, Rieke ;
Pavelka, Karel ;
Klearman, Micki ;
Musselman, David ;
Agarwal, Sunil ;
Green, Jennifer ;
Kavanaugh, Arthur .
LANCET, 2013, 381 (9877) :1541-1550
[2]
American College of Rheumatology Guidelines for Screening, Treatment, and Management of Lupus Nephritis [J].
Hahn, Bevra H. ;
McMahon, Maureen A. ;
Wilkinson, Alan ;
Wallace, W. Dean ;
Daikh, David I. ;
Fitzgerald, John D. ;
Karpouzas, George A. ;
Merrill, Joan T. ;
Wallace, Daniel J. ;
Yazdany, Jinoos ;
Ramsey-Goldman, Rosalind ;
Singh, Karandeep ;
Khalighi, Mazdak ;
Choi, Soo-In ;
Gogia, Maneesh ;
Kafaja, Suzanne ;
Kamgar, Mohammad ;
Lau, Christine ;
Martin, William J. ;
Parikh, Sefali ;
Peng, Justin ;
Rastogi, Anjay ;
Chen, Weiling ;
Grossman, Jennifer M. .
ARTHRITIS CARE & RESEARCH, 2012, 64 (06) :797-808
[3]
2012 Update of the 2008 American College of Rheumatology Recommendations for the Use of Disease-Modifying Antirheumatic Drugs and Biologic Agents in the Treatment of Rheumatoid Arthritis [J].
Singh, Jasvinder A. ;
Furst, Daniel E. ;
Bharat, Aseem ;
Curtis, Jeffrey R. ;
Kavanaugh, Arthur F. ;
Kremer, Joel M. ;
Moreland, Larry W. ;
O'Dell, James ;
Winthrop, Kevin L. ;
Beukelman, Timothy ;
Bridges, S. Louis, Jr. ;
Chatham, W. Winn ;
Paulus, Harold E. ;
Suarez-Almazor, Maria ;
Bombardier, Claire ;
Dougados, Maxime ;
Khanna, Dinesh ;
King, Charles M. ;
Leong, Amye L. ;
Matteson, Eric L. ;
Schousboe, John T. ;
Moynihan, Eileen ;
Kolba, Karen S. ;
Jain, Archana ;
Volkmann, Elizabeth R. ;
Agrawal, Harsh ;
Bae, Sangmee ;
Mudano, Amy S. ;
Patkar, Nivedita M. ;
Saag, Kenneth G. .
ARTHRITIS CARE & RESEARCH, 2012, 64 (05) :625-639
[4]
Adalimumab response in patients with early versus established rheumatoid arthritis: DE019 randomized controlled trial subanalysis [J].
Jamal, Shahin ;
Patra, Kaushik ;
Keystone, Edward C. .
CLINICAL RHEUMATOLOGY, 2009, 28 (04) :413-419
[5]
Interleukin-6 Receptor Inhibition With Tocilizumab Reduces Disease Activity in Rheumatoid Arthritis With Inadequate Response to Disease-Modifying Antirheumatic Drugs The Tocilizumab in Combination With Traditional Disease-Modifying Antirheumatic Drug Therapy Study [J].
Genovese, Mark C. ;
McKay, James D. ;
Nasonov, Evgeny L. ;
Mysler, Eduardo F. ;
da Silva, Nilzio A. ;
Alecock, Emma ;
Woodworth, Thasia ;
Gomez-Rein, Juan J. .
ARTHRITIS AND RHEUMATISM, 2008, 58 (10) :2968-2980
[6]
Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial [J].
Emery, Paul ;
Breedveld, Ferdinand C. ;
Hall, Stephen ;
Durez, Patrick ;
Chang, David J. ;
Robertson, Deborah ;
Singh, Amitabh ;
Pedersen, Ronald D. ;
Koenig, Andrew S. ;
Freundlich, Bruce .
LANCET, 2008, 372 (9636) :375-382
[7]
Adalimumab; a fully human anti–tumor necrosis factor α monoclonal antibody; for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial.[J].Michael E. Weinblatt;Edward C. Keystone;Daniel E. Furst;Larry W. Moreland;Michael H. Weisman;Charles A. Birbara;Leah A. Teoh;Steven A. Fischkoff;Elliot K. Chartash.Arthritis & Rheumatism.2003, 1