Wnt信号通路与椎间盘的发展

被引：20

作者：

梁广胜 ^{[1
]}

殷明 ^{[2
]}

刘玉亮 ^{[1
]}

魏强强 ^{[1
]}

周荣平 ^{[2
]}

殷嫦嫦 ^{[3
]}

机构：

[1] 南昌大学研究生院医学部

[2] 南昌大学第二附属医院骨科

[3] 九江学院生化研究中心

来源：

中国矫形外科杂志 | 2014年 / 05期

关键词：

Wnt信号通路; 椎间盘; 治疗;

D O I：

暂无

中图分类号：

R687.3 [骨骼手术];

学科分类号：

100220 [骨科学];

摘要：

<正>下腰痛,因其高患病率和带来沉重的社会经济负担,成为了一个世界性难题。在众多致病要素中,椎间盘退变(intervertebral disc degeneration,IVDD)是引起腰痛的主要因素之一。椎间盘退变的特点是通过一个级联放大反应-椎间盘微环境改变、细胞衰老或凋亡,进而诱导椎间盘的生化和结构改变-椎间盘的生物学功能最终发生障碍。充分认识椎间盘形态形成、生长和退行性病变的分子机制,能为选择一种最为适当而有效的治疗策略来修复椎间盘退行性病变提

引用

页码：441 / 444

页数：4

共 8 条

[1]

Lumbar Degenerative Disc Disease: Current and Future Concepts of Diagnosis and Management[J] Fadi Taher;David Essig;Darren R. Lebl;Alexander P. Hughes;Andrew A. Sama;Frank P. Cammisa;Federico P. Girardi;Brian R. Subach Advances in Orthopedics 2012,

[2]

Intervertebral Disk Repair by Protein; Gene; or Cell Injection: A Framework for Rehabilitation-Focused Biologics in the Spine[J] Yejia Zhang;Ana Chee;Eugene J.-M.A. Thonar;Howard S. An PM&R 2011,

[3]

Intervertebral Disc Development Is Regulated by Wnt/β-catenin Signaling[J] Naoki Kondo;Takahito Yuasa;Kengo Shimono;Weien Tung;Takahiro Okabe;Rika Yasuhara;Maurizio Pacifici;Yejia Zhang;Masahiro Iwamoto;Motomi Enomoto-Iwamoto Spine 2011,

[4]

Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells[J] Michiru Nishita;Masahiro Enomoto;Kaoru Yamagata;Yasuhiro Minami Trends in Cell Biology 2010,

[5]

Enhancement of intervertebral disc cell senescence by WNT/β‐catenin signaling–induced matrix metalloproteinase expression[J] AkihikoHiyama;DaisukeSakai;Makarand V.Risbud;MasahiroTanaka;FumiyukiArai;KoichiroAbe;JojiMochida Arthritis & Rheumatism 2010,

[6]

Wnt11/5a Complex Formation Caused by Tyrosine Sulfation Increases Canonical Signaling Activity[J] Sang-Wook Cha;Emmanuel Tadjuidje;Jody White;James Wells;Christopher Mayhew;Christopher Wylie;Janet Heasman Current Biology 2009,

[7]

Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord[J] Kanako Ukita;Shino Hirahara;Naoko Oshima;Yu Imuta;Aki Yoshimoto;Chuan-Wei Jang;Masayuki Oginuma;Yumiko Saga;Richard R. Behringer;Hisato Kondoh;Hiroshi Sasaki Mechanisms of Development 2009,

[8]

Transient Activation of Wnt/β-Catenin Signaling Induces Abnormal Growth Plate Closure and Articular Cartilage Thickening in Postnatal Mice[J] Takahito Yuasa;Naoki Kondo;Rika Yasuhara;Kengo Shimono;Susan Mackem;Maurizio Pacifici;Masahiro Iwamoto;Motomi Enomoto-Iwamoto The American Journal of Pathology 2009,

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