热休克蛋白27的抗凋亡机制及在神经保护中的应用

被引：2

作者：

吴庆建 ^{[1
]}

孙树印 ^{[1
]}

闫承军 ^{[1
]}

付晓婷 ^{[2
]}

邵璐荣 ^{[2
]}

张慧芳 ^{[2
]}

杨明峰 ^{[2
]}

孙保亮 ^{[2
]}

机构：

[1] 济宁市第一人民医院急诊科

[2] 泰山医学院生命科学研究中心脑科研究所

来源：

中华老年心脑血管病杂志 | 2017年 / 19卷 / 02期

关键词：

热休克蛋白质类; 氧化性应激; 氨基酸序列; 蛋白质折叠; 细胞凋亡;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

摘要：

<正>热休克蛋白（Hsp）是Ritossa最先在果蝇唾液腺中发现的遗传高度保守的热应激蛋白质家族,又称应激蛋白。其广泛存在于多种生物细胞中,作为分子伴侣（分子伴侣是指在体内帮助其他含多肽的物质正确组装,但不参与其生物学作用）,当遭受氧化应激、高热、缺血等应激时,在蛋白质内稳态、凋亡、侵袭、细胞信号转导中扮演重要角色[1]。基于氨基酸序列和分子量大小,Hsp可分5个家族。Hsp27,鼠类为Hsp25,属于小分子量Hsp家族中的重要成员,普遍存在于

引用

页码：214 / 216

页数：3

共 14 条

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