TLR信号通路研究进展附视频

被引：25

作者：

余益本

王建平

机构：

[1] 南华大学第二附属医院内分泌科

来源：

细胞与分子免疫学杂志 | 2012年 / 12期

基金：

湖南省自然科学基金;

关键词：

病原分子相关模式物; TLR信号通路; TIR结构域相关接头分子;

D O I：

10.13423/j.cnki.cjcmi.006613

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

TLR在识别病原体相关分子中起到关键作用,提示其与免疫炎症相关。TLR在天然免疫反应中不仅可以清除病原体,而且可通过识别病原体相关分子过程中有效建立获得性免疫体系。在TLR介导的细胞信号通路中,接头分子TLR/IL-1R结构域对免疫炎症反应起到了重要的作用,它可产生一些前炎症细胞因子如NO、1型干扰素等,并上调共刺激分子表达。现就TLR与其相关配体作用关系及TLR介导的天然免疫激活进行综述。

引用

页码：1331 / 1334

页数：4

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