11β-羟基类固醇脱氢酶通过改变糖皮质激素活性参与机体多个病理环节

被引：8

作者：

崔同军

叶磊

辛婧

机构：

[1] 漯河市中心医院急诊科

来源：

医学综述 | 2013年 / 19卷 / 01期

关键词：

11β-羟基类固醇脱氢酶; 糖皮质激素; 认知; 代谢综合征; 高血压;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

11β-羟基类固醇脱氢酶(11β-HSD)是糖皮质激素的代谢酶,该酶分为11β-HSD1与11β-HSD2两种亚型。11β-HSD1使无活性的可的松转化为有活性的氢化可的松,参与了肥胖、高血脂、高血糖、高血压等代谢综合征的病理生理过程。另外,高水平的糖皮质激素暴露与神经系统功能紊乱及年龄相关性认知功能障碍有关。11β-HSD2通过使糖皮质激素失活起到保护盐皮质激素受体的作用。反之,11β-HSD2基因缺陷或突变会导致高盐皮质激素综合征,表现为水钠潴留、高血压、低血钾。通过对11β-HSD的功能及其作用机制的深入研究,为代谢综合征及其相关疾病提供了新的治疗方法。

引用

页码：40 / 42

页数：3

共 9 条

[1]

Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1..Barf T;Vallgarda J;Emond R. et al;.J Med Chem.2002, 18

[2]

Type 1 1lbeta-hydroxysteroid dehydrogenase nledimes glueocorlicoid activition and insulin release in pancreatic islets..Davani B;Khan A;Hult M;et a;.J Biol Chem.2000,

[3]

Liver X receptors downregulate11beta-hydroxysteroid dehydrogenase type1expression and activity..Stulnig TM;Oppermann U;Steffensen KR;et al;.Diabetes.2002,

[4]

Overexpression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients [J].

Baudrand, Rene ;

Carvajal, Cristian A. ;

Riquelme, Arnoldo ;

Morales, Mauricio ;

Solis, Nancy ;

Pizarro, Margarita ;

Escalona, Alex ;

Boza, Camilo ;

Perez, Gustavo ;

Dominguez, Angelica ;

Arrese, Marco ;

Fardella, Carlos E. .

OBESITY SURGERY, 2010, 20 (01) :77-83

[5]

11β-hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes [J].

Stulnig, TM ;

Waldhäusl, W .

DIABETOLOGIA, 2004, 47 (01) :1-11

[6]

Effects of the 11β-Hydroxysteroid Dehydrogenase Inhibitor Carbenoxolone on Insulin Sensitivity in Men with Type 2 Diabetes.[J].Robert C. Andrews;Olav Rooyackers;Brian R. Walker.The Journal of Clinical Endocrinology & Metabolism.2003, 1

[7]

Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice [J].