荨麻疹的病理生理与临床

被引：68

作者：

钟华

郝飞

机构：

[1] 第三军医大学西南医院皮肤科

来源：

中华皮肤科杂志 | 2007年 / 40卷 / 10期

关键词：

慢性尊麻疹; 膜表面; 肥大细胞脱颗粒; 病理生理; 风团; 变应原检测; 白三烯; IgE; 受体拮抗剂;

D O I：

暂无

中图分类号：

R758.24 [荨麻疹];

学科分类号：

摘要：

<正>一直以来.荨麻疹的发生被认为是肥大细胞膜表面高亲和力IgE受体(FcεRI)发生交联,引发肥大细胞脱颗粒释放组胺等介质所致。然而,新近研究提示,Ⅰ-Ⅳ型变态反应及非免疫机制均可介导肥大细胞活化。肥大细胞活化后发生脱颗粒、合成炎症因子和脂类代谢物等3个既相对独立又相互关

引用

页码：652 / 654

页数：3

共 8 条

[1] Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE [J].

Boyce, Joshua A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (06) :1415-1418

[2] Pathophysiology of Urticaria [J].

Hennino, A ;

Bérard, F ;

Guillot, I ;

Saad, N ;

Rozières, A ;

Nicolas, JF .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2006, 30 (01) :3-11

[3] Urticaria [J].

Zuberbier, T .

ALLERGY, 2003, 58 (12) :1224-1234

[4] Omalizumab is effective in the long-term control of severe allergic asthma [J].

Lanier, BQ ;

Corren, J ;

Lumry, W ;

Liu, J ;

Fowler-Taylor, A ;

Gupta, N .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2003, 91 (02) :154-159

[5] Acute urticaria with elevated circulating interleukin-6 is resistant to anti-histamine treatment [J].

Fujii, K ;

Konishi, K ;

Kanno, Y ;

Ohgou, N .

JOURNAL OF DERMATOLOGY, 2001, 28 (05) :248-250

[6] Complement dependence of histamine release in chronic urticaria [J].

Ferrer, M ;

Nakazawa, K ;

Kaplan, AP .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 104 (01) :169-172

[7] CAN ANTI-IGE BE USED TO TREAT ALLERGY [J].

DAVIS, FM ;

GOSSETT, LA ;

PINKSTON, KL ;

LIOU, RS ;

SUN, LK ;

KIM, YW ;

CHANG, NT ;

CHANG, TW ;

WAGNER, K ;

BEWS, J ;

BRINKMANN, V ;

TOWBIN, H ;

SUBRAMANIAN, N ;

HEUSSER, C .

SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1993, 15 (01) :51-73

[8]

Autologous whole blood injections to patients with chronic urticaria and a positive auto- logous serum skin test:a placebo-controlled trial. Staubach P,Onnen K,Vonend A,et al. Dermatology . 2006

← 1 →