炎症因子与心率变异性在不稳定心绞痛中的相关性研究

被引：17

作者：

马度芳 ^{[1
]}

姚晓东 ^{[2
]}

庄欣 ^{[2
]}

吴波 ^{[2
]}

王燕 ^{[2
]}

李晓 ^{[2
]}

机构：

[1] 山东中医药大学

[2] 山东中医药大学附属医院

来源：

中国循证心血管医学杂志 | 2015年 / 7卷 / 02期

关键词：

不稳定心绞痛; 心率变异性; 超敏C反应蛋白; 白介素6; 相关性分析;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

目的研究不稳定心绞痛(UA)患者炎性标志物与心率变异性之间的关系。方法自2013年6月至2014年6月在山东中医药大学附属医院心内科住院的UA患者40例,女性26例,男性14例,年龄5080岁。将研究对象分为hs-CRP<1.0组mg/L(n=15),hs-CRP(1.03.0)mg/L组(n=16),hs-CRP>3.0 mg/L组(n=9)。所有患者进行24 h动态心电图检测获取心率变异性(HRV),计算时域指标及频域指标。同时检测炎症因子超敏C反应蛋白(hs-CRP)和白介素-6(IL-6)含量。分析hsCRP、IL-6的自然对数与SDNN、RMSSD的关系。结果 hs-CRP(>3 mg/L)组较hs-CRP(13 mg/L)组SDNN和RMSSD均降低,差异有统计学意义(P均<0.05)。各组间频域指标比较,随hs-CRP的升高,其低频(LF)、高频(HF)、极低频(VLF)和总功率(TP)逐渐降低,但各组间差异无统计学意义(P均>0.05)。单因素相关分析显示hs-CRP自然对数(Lnhs-CRP)与SDNN之间存在负相关性(r=-0.365,P=0.022),而Lnhs-CRP与RMSSD之间无明显相关。IL-6自然对数(Ln IL-6)与SDNN呈负相关(r=-0.700,P<0.001),与RMSSD呈负相关(r=-0.457,P=0.003)。结论 UA患者HRV的降低与体内炎性标记物hs-CRP、IL-6增加相关。

引用

页码：211 / 214+224 +224

页数：5

共 12 条

[1]

An inverse correlation between TNF alpha serum levels and heart rate variability in patients with heart failure[J] Valentina N. Nikolic;Tatjana Jevtovic-Stoimenov;Dragana Stokanovic;Milena Milovanovic;Radmila Velickovic-Radovanovic;Srdjan Pesic;Milan Stoiljkovic;Gordana Pesic;Stevan Ilic;Marina Deljanin-Ilic;Dragan Marinkovic;Nikola Stefanovic;Slobodan M. Jankovic Journal of Cardiology 2013,

[2]

Sympathetic Nervous System Modulation of Inflammation and Remodeling in the Hypertensive Heart[J] Scott P. Levick;David B. Murray;Joseph S. Janicki;Gregory L. Brower Hypertension 2010,

[3]

Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men[J] Rachel Lampert;J. Douglas Bremner;Shaoyong Su;Andrew Miller;Forrester Lee;Faiz Cheema;Jack Goldberg;Viola Vaccarino American Heart Journal 2008,

[4]

Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients With Unstable Angina Pectoris[J] Gaetano A. Lanza;Gregory Angelo Sgueglia;Domenico Cianflone;Antonio G. Rebuzzi;Giulia Angeloni;Alfonso Sestito;Fabio Infusino;Filippo Crea;Attilio Maseri The American Journal of Cardiology 2006,

[5]

On the genesis of myocardial ischemia[J] K. Sroka Zeitschrift für Kardiologie 2004,

[6]

Clinical Application of C-Reactive Protein for Cardiovascular Disease Detection and Prevention[J] Paul M Ridker Circulation: Journal of the American Heart Association 2003,

[7]

Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association[J] Thomas A. Pearson;George A. Mensah;R. Wayne Alexander;Jeffrey L. Anderson;Richard O. Cannon;Michael Criqui;Yazid Y. Fadl;Stephen P. Fortmann;Yuling Hong;Gary L. Myers;Nader Rifai;Sidney C. Smith;Kathryn Taubert;Russell P. Tracy;Frank Vinicor Circulation: Journal of

[8]

Heart rate variability and cardiovascular mortality[J] Rollo P. Villareal;Brant C. Liu;Ali Massumi Current Atherosclerosis Reports 2002,

[9]

Elevated C-Reactive Protein Values and Atherosclerosis in Sudden Coronary Death: Association With Different Pathologies[J] Allen P. Burke;Russell P. Tracy;Frank Kolodgie;Gray T. Malcom;Arthur Zieske;Robert Kutys;Joseph Pestaner;John Smialek;Renu Virmani Circulation: Journal of the American Heart Association 2002,

[10]

High-Sensitivity C-Reactive Protein: Potential Adjunct for Global Risk Assessment in the Primary Prevention of Cardiovascular Disease[J] Paul M. Ridker Circulation: Journal of the American Heart Association 2001,

← 1 2 →