GAP-43免疫反应神经纤维对发育中大鼠脾脏支配的研究

被引：2

作者：

杨宏

邱建勇

鞠躬

机构：

[1] 第四军医大学神经科学研究所!西安

来源：

神经解剖学杂志 | 1997年 / 01期

关键词：

生长相关蛋白; 脾脏; 发育; 免疫组织化学; 大鼠;

D O I：

暂无

中图分类号：

R322 [人体解剖学];

学科分类号：

100101 ;

摘要：

本实验用免疫组化方法研究了含生长相关蛋白（GAP－43）的神经纤维在新生、幼年、成年大鼠脾脏的分布及发育规律、结果显示，在出生第1d，GAP－43免疫反应阳性神经纤维团簇即出现于尚在形成中的白髓（原基）中．根据形态可将它们分粗直和细网两种类型．至生后第10d，随着脾脏的迅速发育，GAP－43免疫反应阳性神经纤维的密度也达最高峰，它们大量出现于脾脏的血管系统周围和白、红髓内，其形态演变为具有膨体的细纤维．在生后20d，除脾脏的血管周围外，GAP－43阳性纤维密度有所下降，只出现于脾小体和被膜等结构内。在成年大鼠脾脏，除上述部位外，阳性纤维明显见于发育成熟的小梁中。本研究发现，GAP－43免疫反应阳性神经纤维密度在脾脏发育各阶段有所不同，以生后第10d为最多．本研究还就含GAP－43神经在发育中脾脏的分布规律与含TH能神经成分做了比较．

引用

页码：1 / 5

页数：5

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