轻型缺血性脑卒中患者急性期神经功能恶化的相关因素分析

被引:35
作者
李菁晶
鞠奕
潘岳松
赵性泉
王拥军
机构
[1] 首都医科大学附属北京天坛医院神经精神医学与临床心理科神经病学中心血管神经病学科国家神经系统疾病临床医学研究中心北京脑重大疾病研究院脑卒中研究所脑血管病转化医学北京重点实验室
关键词
卒中; 糖尿病; 脑梗死; 感染;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
100204 [神经病学];
摘要
目的观察中国国家卒中登记(CNSR)研究中轻型缺血性脑卒中患者急性期神经功能恶化的相关因素。方法以2007年9月2008年8月CNSR收集的22 216例急性脑血管病患者资料为数据来源,符合入组标准轻型缺血性脑卒中患者2424例,根据临床预后分为恶化组368例,未恶化组2056例,通过单因素和多因素分析寻找与急性期神经功能恶化相关的因素。结果恶化组患者住院时间、糖尿病、新发脑卒中、急性感染、痫性发作、应激性血糖升高、下肢深静脉血栓和肺栓塞发生率较未恶化组明显增高,差异有统计学意义(P<0.05,P<0.01)。多因素logistic回归分析显示,入院NIHSS评分(OR=1.08,95%CI:1.03~1.13,P=0.003)、糖尿病(OR=1.73,95%CI:1.26~2.37,P=0.001)、新发脑卒中(OR=9.07,95%CI:5.39~15.26,P=0.000)和急性感染(OR=2.37,95%CI:1.50~3.76,P=0.000)是急性期神经功能恶化的独立预测因素。结论糖尿病、入院NIHSS评分、新发脑卒中、急性感染可能是轻型缺血性脑卒中患者急性期神经功能恶化风险升高的预测因素。
引用
收藏
页码:715 / 718
页数:4
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