α-突触核蛋白及其在帕金森病发病中的可能机制

被引：22

作者：

张萍

刘康永

蔡增林

刘春风

机构：

[1] 苏州大学附属第二医院神经内科

来源：

中国临床神经科学 | 2008年 / 05期

关键词：

α-突触核蛋白; 帕金森病; Lewy体; 自噬;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

100204 [神经病学];

摘要：

α-突触核蛋白(AS)是Lewy体的重要组成成分。AS基因定位于第4号染色体,其突变型与常染色体显性遗传性帕金森病(PD)的发病密切相关。在PD中,AS出现了折叠错误和排列混乱。AS的聚集能力,特别是在氧化应激状态下,被认为是其病理机制的核心,AS的异常聚集和降解障碍导致蛋白酶的抑制和多巴胺能神经元的死亡。因此,AS致病形式对认识PD的发生有重要意义。

引用

收藏

页码：556 / 561

页数：6

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