老年男性冠心病患者血清睾酮水平与内皮功能的关系

被引：8

作者：

龚群林 ^{[1
]}

章紫燕 ^{[2
]}

陈似俊 ^{[3
]}

机构：

[1] 同济大学附属杨浦医院

[2] 上海华山医院东院

[3] 天津医科大学临床医学院

来源：

山东医药 | 2014年 / 54卷 / 08期

关键词：

冠状动脉粥样硬化性性心脏病; 睾酮; 内皮功能; 非对称二甲基精氨酸; 一氧化氮;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

目的观察老年男性冠心病患者血清睾酮水平变化,并分析其与内皮功能指标非对称二甲基精氨酸(ADMA)、NO之间的关系。方法按入院顺序随机选取124例年龄65～80岁的老年男性患者,分为冠心病组、对照组各62例。采用ELISA法检测血清睾酮、ADMA,双抗体夹心法检测NO;比较两组睾酮、ADMA、NO水平,分析睾酮水平与ADMA、NO的关系。结果冠心病组血清睾酮为(4.14±1.70)ng/L、ADMA为(391.02±14.16)μmol/L、NO为(61.96±14.76)mol/L,对照组分别为(5.21±0.86)ng/L、(377.56±17.46)μmol/L、(86.42±16.86)mol/L,P均<0.01。直线相关分析显示,冠心病组血清睾酮与ADMA水平呈负相关(r=-0.474,P<0.01),与NO水平呈正相关(r=0.456,P<0.01)。结论老年男性冠心病患者血清睾酮、NO呈低水平状态,而血清ADMA水平显著升高;睾酮水平降低可能通过影响ADMA调节NO的释放,从而抑制内皮功能导致老年冠心病发生、发展。

引用

页码：38 / 40

页数：3

共 9 条

[1]

十一酸睾酮对雄性家兔髂动脉内膜损伤后的修复作用 [J].

楼亚梅 ;

徐哲荣 ;

杨云梅 ;

归琦峰 .

中国动脉硬化杂志, 2007, (04) :272-276

[2]

Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) prospective population study [J].

Khaw, Kay-Tee ;

Dowsett, Mitch ;

Folkerd, Elizabeth ;

Bingham, Sheila ;

Wareham, Nicholas ;

Luben, Robert ;

Welch, Ailsa ;

Day, Nicholas .

CIRCULATION, 2007, 116 (23) :2694-2701

[3]

Physiological testosterone replacement therapy attenuates fatty streak formation and improves high-density lipoprotein cholesterol in the Tfm mouse: An effect that is independent of the classic androgen receptor [J].

Nettleship, Joanne E. ;

Jones, T. Hugh ;

Channer, Kevin S. ;

Jones, Richard D. .

CIRCULATION, 2007, 116 (21) :2427-2434

[4]

Endogenous testosterone and endothelial function in postmenopausal women [J].

Montalcini, Tiziana ;

Gorgone, Gaetano ;

Gazzaruso, Carmine ;

Sesti, Giorgio ;

Perticone, Francesco ;

Pujia, Arturo .

CORONARY ARTERY DISEASE, 2007, 18 (01) :9-13

[5]

The association between androgen levels and premature coronary artery disease in men [J].

Turhan, Sibel ;

Tulunay, Cansin ;

Gulec, Sadi ;

Ozdol, Cagdas ;

Kilickap, Mustafa ;

Altin, Timucin ;

Gerede, Menekse ;

Erol, Cetin .

CORONARY ARTERY DISEASE, 2007, 18 (03) :159-162

[6]

Reduced number of circulating endothelial progenitor cells in hypogonadal men [J].

Foresta, C. ;

Caretta, N. ;

Lana, A. ;

De Toni, L. ;

Biagioli, A. ;

Ferlin, A. ;

Garolla, A. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (11) :4599-4602

[7]

Asymmetric dimethylarginine is an independent risk factor for coronary heart disease:: Results from the multicenter coronary artery risk determination investigating the influence of ADMA concentration (CARDIAC) study [J].

Schulze, Friedrich ;

Lenzen, Henrike ;

Hanefeld, Christoph ;

Bartling, Asja ;

Osterziel, Karl J. ;

Goudeva, Lilia ;

Schmidt-Lucke, Caroline ;

Kusus, Magda ;

Maas, Renke ;

Schwedhelm, Edzard ;

Stroedter, Dietrich ;

Simon, Bernd C. ;

Muegge, Andreas ;

Daniel, Werner G. ;

Tillmanns, Harald ;

Maisch, Bernhard ;

Streichert, Thomas ;

Boeger, Rainer H. .

AMERICAN HEART JOURNAL, 2006, 152 (03) :493.e1-493.e8

[8]

The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men [J].

Malkin, CJ ;

Pugh, PJ ;

Jones, RD ;

Kapoor, D ;

Channer, KS ;

Jones, TH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (07) :3313-3318

[9]

Testosterone supplementation in men with type 2 diabetes; visceral obesity and partial androgen deficiency.[J].M. A. Boyanov;Z. Boneva;V. G. Christov.The Aging Male.2003, 1

← 1 →