他汀类药物抗凝作用的研究进展

被引:8
作者
王震
魏玉杰
刘惠亮
机构
[1] 安徽医科大学武警总医院临床学院
关键词
他汀类药物; 血液凝固; 凝血因子; 抗凝物质;
D O I
10.20039/j.cnki.1007-3949.2016.03.020
中图分类号
R96 [药理学];
学科分类号
100706 [药理学];
摘要
他汀类药物可以用于降低血清胆固醇,因其降脂作用而被应用于冠心病等心血管疾病的预防和控制。随着对他汀类药物研究的不断深入,发现他汀类药物具有抗凝作用,主要体现在降低深静脉血栓形成风险、调节凝血因子的表达、影响生理性抗凝物质,以及通过对炎症和内皮功能调节等方面。文章就他汀类药物的抗凝作用做一综述。
引用
收藏
页码:316 / 320
页数:5
相关论文
共 23 条
[1]
不同剂量瑞舒伐他汀对ACS患者血清hs-CRP、TXβ及Hcy浓度的影响 [J].
孙秀才 ;
曾辉 ;
施霞 ;
孟娟 .
中国动脉硬化杂志 , 2014, (04) :387-390
[2]
辛伐他汀对香烟烟雾提取物诱导的人脐静脉内皮细胞表达sEPCR和mEPCR的影响 [J].
樊芳芳 ;
胡晓芸 ;
扈丽娟 ;
韩葆芬 ;
赵瑛娟 .
中国病理生理杂志, 2012, 28 (04) :727-729
[3]
Associations Between Inflammatory Markers, Hemostatic Markers, and Microvascular Complications in 182 Chinese Patients With Type 2 Diabetes Mellitus [J].
Zheng, Nengneng ;
Shi, Xinping ;
Chen, Xiongwei ;
Lv, Wen .
LABMEDICINE, 2015, 46 (03) :214-220
[4]
Aberrant Circulating Levels of Purinergic Signaling Markers Are Associated With Several Key Aspects of Peripheral Atherosclerosis and Thrombosis [J].
Jalkanen, Juho ;
Yegutkin, Gennady G. ;
Hollmen, Maija ;
Aalto, Kristiina ;
Kiviniemi, Tuomas ;
Salomaa, Veikko ;
Jalkanen, Sirpa ;
Hakovirta, Harri .
CIRCULATION RESEARCH, 2015, 116 (07) :1206-+
[5]
Systemic inflammation in xenograft recipients precedes activation of coagulation [J].
Ezzelarab, Mohamed B. ;
Ekser, Burcin ;
Azimzadeh, Agnes ;
Lin, Chih Che ;
Zhao, Yuming ;
Rodriguez, Rachael ;
Echeverri, Gabriel J. ;
Iwase, Hayato ;
Long, Cassandra ;
Hara, Hidetaka ;
Ayares, David ;
Pierson, Richard N. ;
Thomson, Angus W. ;
Cooper, David K. .
XENOTRANSPLANTATION, 2015, 22 (01) :32-47
[6]
Statins are Associated with Low Risk of Venous Thromboembolism in Patients with Cancer: A Prospective and Observational Cohort Study. [J].
Loetsch, Felix ;
Koenigsbruegge, Oliver ;
Posch, Florian ;
Zielinski, Christoph ;
Pabinger, Ingrid ;
Ay, Cihan .
THROMBOSIS RESEARCH, 2014, 134 (05) :1008-1013
[7]
Hyperlipidemia, tissue factor, coagulation, and simvastatin [J].
Owens, Albert Phillip, III ;
Byrnes, James Robert ;
Mackman, Nigel .
TRENDS IN CARDIOVASCULAR MEDICINE, 2014, 24 (03) :95-98
[8]
Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats [J].
Rodrigo Camara-Lemarroy, Carlos ;
Javier Guzman-de la Garza, Francisco ;
Alarcon-Galvan, Gabriela ;
Cordero-Perez, Paula ;
Munoz-Espinosa, Linda ;
Torres-Gonzalez, Liliana ;
Esthela Fernandez-Garza, Nancy .
ARCHIVES OF MEDICAL RESEARCH, 2014, 45 (03) :210-216
[9]
Nitric oxide releasing material adsorbs more fibrinogen [J].
Lantvit, Sarah M. ;
Barrett, Brittany J. ;
Reynolds, Melissa M. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2013, 101 (11) :3201-3210
[10]
Role of Krüppel-Like Factor 2 and Protease-Activated Receptor-1 in Vulnerable Plaques of ApoE ?/? Mice and Intervention With Statin.[J].Lixia Yang;Xiaobin Zhou;Ruiwei Guo;Yankun Shi;Xing Liang;Xuhua Heng.Canadian Journal of Cardiology.2013, 8