区域选择性改性的纤维素和壳聚糖衍生物及其血液相容性

被引：1

作者：

刘春

机构：

[1] 大连理工大学精细化工国家重点实验室

来源：

生物加工过程 | 2008年 / 01期

基金：

教育部留学回国人员科研启动基金;

关键词：

血液相容性; 纤维素; 壳聚糖; 改性; 区域选择性;

D O I：

暂无

中图分类号：

R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

通过对纤维素和壳聚糖的区域选择性改性,将内皮细胞表面硫酸乙酰肝素(ES-HS)分子结构中对其血液相容性有重要影响的官能团引入纤维素和壳聚糖的分子结构中,并将其通过离子键固定在部分阳离子化的纤维素膜上,以期模拟ES-HS的血液相容性。血小板吸附结果表明,6位改性的纤维素衍生物的吸附程度较高。在五种壳聚糖衍生物中,2位的NSO3/NAc为6/4的衍生物表现出最低的血小板吸附。当保持壳聚糖2位的NSO3/NAc值不变时,对6位进行完全磺酸酯化,也可有效减少血小板的吸附。

引用

页码：65 / 68

页数：4

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