脑缺血再灌注后生长相关蛋白和突触素表达及其意义

被引：3

作者：

丰岩清

郭云良

石秉霞

机构：

[1] 青岛大学医学院脑血管病研究所!青岛

来源：

青岛大学医学院学报 | 2000年 / 04期

关键词：

生长相关蛋白; 突触蛋白类; 脑缺血; 大鼠;

D O I：

10.13361/j.qdyxy.2000.04.006

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

1目的　研究脑缺血再灌注后生长相关蛋白 - 43(GAP- 43)和突触素 p38表达的变化规律 ,探讨中枢神经损伤后修复的可塑性。 2方法　成年健康雌性 Wistar大鼠 36只 ,随机分为实验组和对照组。采用线栓法建立大脑中动脉缺血再灌注大鼠模型 ,应用免疫组织化学方法观察脑缺血再灌注后 GAP- 43和突触素 p38的表达。 3结果　脑缺血再灌注 6 h后 ,GAP- 43表达逐渐增高 ,第 7天达高峰 ,以后逐渐降低 ,第 2 1天仍有表达。脑缺血再灌注 1d后突触素 p38表达增高 ,第 7天达高峰 ,之后逐渐降低 ,第 2 1天降至对照组水平。4结论　中枢神经系统损伤后 ,神经元具有再生和修复的可塑性 ,GAP- 43和突触素 p38是神经损伤和修复的分子标志物。

引用

页码：247 / 249

页数：3

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