miR-21高表达对非小细胞肺癌患者整体生存率影响的Meta分析

被引：7

作者：

李军

刘庆云

辛江泽

机构：

[1] 山东省医学科学院附属医院

来源：

基因组学与应用生物学 | 2019年 / 38卷 / 11期

关键词：

miR-21; 非小细胞肺癌; 整体生存率;

D O I：

10.13417/j.gab.038.005193

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

100117 [系统生物医学];

摘要：

本研究通过Meta分析探究了miR-21的高表达对非小细胞肺癌(NSCLC)患者整体生存率(OS)的影响。通过检索Pubmed、Medline、EMBASE、CNKI和万方中文科技期刊数据库,收集关于miR-21的高表达对NSCLC患者整体生存率影响的文献,参照Newcastle-Ottawa Scale (NOS)评价标准对文献质量进行评估,本研究使用Revman 5.3软件对各研究的效应量进行了合并分析。本研究共纳入8篇文献(共1 037案例),OS的HR合并值为1.28 (95%CI:1.15～1.43,p<0.001)。对纳入文献进行亚组分析,结果发现血清和组织中miR-21的高表达均预示着NSCLC患者OS降低(组织HR=1.74,95%CI:1.08～2.80,p<0.05;血清HR=1.98,95%CI:1.22～3.20,p<0.001)。本研究初步表明,miR-21的高表达预示着NSCLC患者OS降低。

引用

页码：5193 / 5197

页数：5

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