TCR β链CDR3谱序与疾病研究概况及进展

被引：15

作者：

姚新生

机构：

[1] 遵义医学院免疫学教研室

来源：

国际免疫学杂志 | 2007年 / 04期

关键词：

免疫扫描谱型分析; CDR3; 自身免疫性疾病; 超抗原; 肿瘤;

D O I：

暂无

中图分类号：

R3 [基础医学];

学科分类号：

1001 ;

摘要：

近年来,T细胞受体(TCR)互补决定区(CDR)和机体的生理、病理关系研究取得了较大的进展,尤其是在超抗原作用的感染性疾病、自身免疫性疾病、肿瘤等疾病状态下,TCR β链CDR3谱型能很好地反映T细胞的功能,通过TCRβ链CDR3谱型来研究克隆性和寡克隆性增生T细胞,可了解T细胞免疫与疾病发生发展的关系,指导疾病的诊断及免疫治疗,同时可了解正常情况下T细胞的发生和发展情况。

引用

页码：240 / 244

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