干扰素基因刺激蛋白信号通路与感染性及自身免疫性疾病的相关性研究进展

被引：7

作者：

王容

黄国锦

机构：

[1] 桂林医学院附属医院呼吸疾病实验室

来源：

广西医学 | 2018年 / 40卷 / 05期

关键词：

环鸟苷酸-腺苷酸合成酶; 干扰素基因刺激蛋白; 信号转导; 感染性疾病; 自身免疫性疾病; 综述;

D O I：

暂无

中图分类号：

R593.2 [自身免疫性疾病、结缔组织疾病];

学科分类号：

100201 [内科学];

摘要：

环鸟苷酸-腺苷酸合成酶(cGAS)是近年新发现的一种细胞内DNA感受器,能催化合成环鸟苷酸-腺苷酸激活干扰素基因刺激蛋白(STING),进而引起一系列下游分子激活,最终诱导产生Ⅰ型干扰素(IFN)。越来越多的研究证明cGAS-STING信号通路在固有免疫过程中发挥重要作用。cGAS-STING信号通路参与识别进入胞内微生物的DNA及自身DNA,并在感染性疾病和自身免疫性疾病发病过程中发挥重要作用。本文就对cGAS-STING信号通路与感染性及自身免疫性疾病的相关性研究进展进行综述。

引用

页码：566 / 569

页数：4

共 15 条

[1]

Cyclic GMP–AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.[J].Kazuki Kato;Hiroki Omura;Ryuichiro Ishitani;Osamu Nureki.Annual Review of Biochemistry.2017, 1

[2]

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases [J].

Gao, Daxing ;

Li, Tuo ;

Li, Xiao-Dong ;

Chen, Xiang ;

Li, Quan-Zhen ;

Wight-Carter, Mary ;

Chen, Zhijian J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (42) :E5699-E5705

[3]

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1 [J].

Yoh, Sunnie M. ;

Schneider, Monika ;

Seifried, Janna ;

Soonthornvacharin, Stephen ;

Akleh, Rana E. ;

Olivieri, Kevin C. ;

De Jesus, Paul D. ;

Ruan, Chunhai ;

de Castro, Elisa ;

Ruiz, Pedro A. ;

Germanaud, David ;

des Portes, Vincent ;

Garcia-Sastre, Adolfo ;

Koenig, Renate ;

Chanda, Sumit K. .

CELL, 2015, 161 (06) :1293-1305

[4]

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein [J].

Wu, Jian-jun ;

Li, Wenwei ;

Shao, Yaming ;

Avey, Denis ;

Fu, Bishi ;

Gillen, Joseph ;

Hand, Travis ;

Ma, Siming ;

Liu, Xia ;

Miley, Wendell ;

Konrad, Andreas ;

Neipel, Frank ;

Stuerzl, Michael ;

Whitby, Denise ;

Li, Hong ;

Zhu, Fanxiu .

CELL HOST & MICROBE, 2015, 18 (03) :333-344

[5]

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis [J].

Collins, Angela C. ;

Cai, Haocheng ;

Li, Tuo ;

Franco, Luis H. ;

Li, Xiao-Dong ;

Nair, Vidhya R. ;

Scharn, Caitlyn R. ;

Stamm, Chelsea E. ;

Levine, Beth ;

Chen, Zhijian J. ;

Shiloh, Michael U. .

CELL HOST & MICROBE, 2015, 17 (06) :820-828

[6]

Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation [J].

Nissen, S. K. ;

Hojen, J. F. ;

Andersen, K. L. D. ;

Kofod-Olsen, E. ;

Berg, R. K. ;

Paludan, S. R. ;

Ostergaard, L. ;

Jakobsen, M. R. ;

Tolstrup, M. ;

Mogensen, T. H. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 177 (01) :295-309

[7]

Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses [J].

Liang, Qiming ;

Seo, Gil Ju ;

Choi, Youn Jung ;

Kwak, Mi-Jeong ;

Ge, Jianning ;

Rodgers, Mary A. ;

Shi, Mude ;

Leslie, Benjamin J. ;

Hopfner, Karl-Peter ;

Ha, Taekjip ;

Oh, Byung-Ha ;

Jung, Jae U. .

CELL HOST & MICROBE, 2014, 15 (02) :228-238

[8]

Activated STING in a Vascular and Pulmonary Syndrome [J].

Liu, Y. ;

Jesus, A. A. ;

Marrero, B. ;

Yang, D. ;

Ramsey, S. E. ;

Sanchez, G. A. Montealegre ;

Tenbrock, K. ;

Wittkowski, H. ;

Jones, O. Y. ;

Kuehn, H. S. ;

Lee, C. -C. R. ;

DiMattia, M. A. ;

Cowen, E. W. ;

Gonzalez, B. ;

Palmer, I. ;

DiGiovanna, J. J. ;

Biancotto, A. ;

Kim, H. ;

Tsai, W. L. ;

Trier, A. M. ;

Huang, Y. ;

Stone, D. L. ;

Hill, S. ;

Kim, H. J. ;

St Hilaire, C. ;

Gurprasad, S. ;

Plass, N. ;

Chapelle, D. ;

Horkayne-Szakaly, I. ;

Foell, D. ;

Barysenka, A. ;

Candotti, F. ;

Holland, S. M. ;

Hughes, J. D. ;

Mehmet, H. ;

Issekutz, A. C. ;

Raffeld, M. ;

McElwee, J. ;

Fontana, J. R. ;

Minniti, C. P. ;

Moir, S. ;

Kastner, D. L. ;

Gadina, M. ;

Steven, A. C. ;

Wingfield, P. T. ;

Brooks, S. R. ;

Rosenzweig, S. D. ;

Fleisher, T. A. ;

Deng, Z. ;

Boehm, M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (06) :507-518

[9]

The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling [J].

Zhou, Qian ;

Lin, Heng ;

Wang, Suyun ;

Wang, Shuai ;

Ran, Yong ;

Liu, Ying ;

Ye, Wen ;

Xiong, Xiaozhe ;

Zhong, Bo ;

Shu, Hong-Bing ;

Wang, Yan-Yi .

CELL HOST & MICROBE, 2014, 16 (04) :450-461

[10]

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects [J].

Li, Xiao-Dong ;

Wu, Jiaxi ;

Gao, Daxing ;

Wang, Hua ;

Sun, Lijun ;

Chen, Zhijian J. .

SCIENCE, 2013, 341 (6152) :1390-1394

← 1 2 →