血小板功能检测在经皮冠状动脉介入治疗患者应用新型抗血小板药物中的作用

被引:7
作者
吴思婧
赵迎新
周志明
刘巍
申华
王乐
于一
贾硕
周玉杰
机构
[1] 首都医科大学附属北京安贞医院北京市心肺血管疾病研究所
关键词
综述; 血小板功能试验; 冠状动脉疾病; 血管成形术,经腔,经皮; 血小板聚集抑制剂;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
100201 [内科学];
摘要
抗血小板治疗现已成为冠心病治疗的基石,尤其是接受经皮冠状动脉介入治疗(PCI)的患者均须接受阿司匹林与P2Y12受体拮抗剂双联抗血小板治疗。而不同患者对于抗血小板药物的反应并不完全一致,由此引发心内科医生的疑问:进行血小板功能检测,是否可以预判患者血栓/出血风险?能否指导患者的治疗策略?本文将从血小板功能检测方法、P2Y12受体拮抗剂的血小板反应多样性、P2Y12受体拮抗剂治疗血小板功能与临床事件关系及现有专家共识推荐等几方面进行回顾与分析。
引用
收藏
页码:1245 / 1248
页数:4
相关论文
共 14 条
[1]
Platelet Inhibition With Ticagrelor 60 mg Versus 90 mg Twice Daily in the PEGASUS-TIMI 54 Trial [J].
Storey, Robert F. ;
Angiolillo, Dominick J. ;
Bonaca, Marc P. ;
Thomas, Mark R. ;
Judge, Heather M. ;
Rollini, Fabiana ;
Franchi, Francesco ;
Ahsan, Arif J. ;
Bhatt, Deepak L. ;
Kuder, Julia F. ;
Steg, Philippe Gabriel ;
Cohen, Marc ;
Muthusamy, Rangasamy ;
Braunwald, Eugene ;
Sabatine, Marc S. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (10) :1145-1154
[2]
"East Asian Paradox": Challenge for the Current Antiplatelet Strategy of "One-Guideline-Fits-All Races" in Acute Coronary Syndrome [J].
Jeong, Young-Hoon .
CURRENT CARDIOLOGY REPORTS, 2014, 16 (05)
[3]
Response Variability to P2Y 12 Receptor Inhibitors.[J].Jolanta M. Siller-Matula;Dietmar Trenk;Karsten Schrör;Meinrad Gawaz;Steen D. Kristensen;Robert F. Storey;Kurt Huber.JACC: Cardiovascular Interventions.2013, 11
[4]
Platelet reactivity evaluated with the VASP assay following ticagrelor loading dose in acute coronary syndrome patients undergoing percutaneous coronary intervention [J].
Laine, Marc ;
Toesca, Richard ;
Berbis, Julie ;
Frere, Corinne ;
Barnay, Pierre ;
Pansieri, Michel ;
Peyre, Jean-Pascal ;
Michelet, Pierre ;
Bessereau, Jacques ;
Camilleri, Elise ;
Helaf, Olfa ;
Camaleonte, Marjorie ;
Paganelli, Franck ;
Dignat-George, Franoise ;
Bonello, Laurent .
THROMBOSIS RESEARCH, 2013, 132 (01) :E15-E18
[5]
Comparison of Prasugrel and Ticagrelor Loading Doses in ST-Segment Elevation Myocardial Infarction Patients.[J].Guido Parodi;Renato Valenti;Benedetta Bellandi;Angela Migliorini;Rossella Marcucci;Vincenzo Comito;Nazario Carrabba;Alberto Santini;Gian Franco Gensini;Rosanna Abbate;David Antoniucci.Journal of the American College of Cardiology.2013, 15
[6]
Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study [J].
Stone, Gregg W. ;
Witzenbichler, Bernhard ;
Weisz, Giora ;
Rinaldi, Michael J. ;
Neumann, Franz-Josef ;
Metzger, D. Christopher ;
Henry, Timothy D. ;
Cox, David A. ;
Duffy, Peter L. ;
Mazzaferri, Ernest ;
Gurbel, Paul A. ;
Xu, Ke ;
Parise, Helen ;
Kirtane, Ajay J. ;
Brodie, Bruce R. ;
Mehran, Roxana ;
Stuckey, Thomas D. .
LANCET, 2013, 382 (9892) :614-623
[7]
Consensus and Update on the Definition of On-Treatment Platelet Reactivity to Adenosine Diphosphate Associated With Ischemia and Bleeding [J].
Tantry, Udaya S. ;
Bonello, Laurent ;
Aradi, Daniel ;
Price, Matthew J. ;
Jeong, Young-Hoon ;
Angiolillo, Dominick J. ;
Stone, Gregg W. ;
Curzen, Nick ;
Geisler, Tobias ;
ten Berg, Jurrien ;
Kirtane, Ajay ;
Siller-Matula, Jolanta ;
Mahla, Elisabeth ;
Becker, Richard C. ;
Bhatt, Deepak L. ;
Waksman, Ron ;
Rao, Sunil V. ;
Alexopoulos, Dimitrios ;
Marcucci, Rossella ;
Reny, Jean-Luc ;
Trenk, Dietmar ;
Sibbing, Dirk ;
Gurbel, Paul A. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (24) :2261-2273
[8]
Randomized Assessment of Ticagrelor Versus Prasugrel Antiplatelet Effects in Patients with ST-Segment–Elevation Myocardial Infarction.[J].Dimitrios Alexopoulos;Ioanna Xanthopoulou;Vassilios Gkizas;George Kassimis;Konstantinos C. Theodoropoulos;George Makris;Nikolaos Koutsogiannis;Anastasia Damelou;Grigorios Tsigkas;Periklis Davlouros;George Hahalis.Circulation: Cardiovascular Interventions.2012, 6
[9]
Ticagrelor Versus Prasugrel in Acute Coronary Syndrome Patients With High On-Clopidogrel Platelet Reactivity Following Percutaneous Coronary Intervention.[J].Dimitrios Alexopoulos;Anastasia Galati;Ioanna Xanthopoulou;Eleni Mavronasiou;George Kassimis;Konstantinos C. Theodoropoulos;George Makris;Anastasia Damelou;Grigorios Tsigkas;George Hahalis;Periklis Davlouros.Journal of the American College of Cardiology.2012, 3
[10]
Platelet Reactivity and Cardiovascular Outcomes After Percutaneous Coronary Intervention A Time-Dependent Analysis of the Gauging Responsiveness With a VerifyNow P2Y12 Assay: Impact on Thrombosis and Safety (GRAVITAS) Trial [J].
Price, Matthew J. ;
Angiolillo, Dominick J. ;
Teirstein, Paul S. ;
Lillie, Elizabeth ;
Manoukian, Steven V. ;
Berger, Peter B. ;
Tanguay, Jean-Francois ;
Cannon, Christopher P. ;
Topol, Eric J. .
CIRCULATION, 2011, 124 (10) :1132-1137